cognitive dysfunction
Conditions
Interventions
Instability Resistance Training (IRT) program: A total of 175 participants allocated to the IRT will be engaged in an exercise program twice weekly for 6 months on alternate days (e.g., Monday and Wed
or Tuesday and Thursday). The training program will consist of seven exercises (swiss ball squat, chest press, front lunges, inverted row using suspension bands, pelvic elevation, standing plantar fle
abdominal/core exercises will be performed for either 15 to 30RM or 10 to 30 seconds of isometric contractions. The average duration expected of each training session will be of roughly 50 to 60 minut
or Tuesday and Thursday), lasting 50 to 60 minutes per session, at the same time of day (8 to 11 a.m.). Among the planned activities will be sessions of strengthening exercise using only body weight (
E05.318.370.074
G11.427.410.698.277
Sponsors
Universidade Federal do Vale do São Francisco - UNIVASF
Universidade Federal do Vale do São Francisco - UNIVASF
Universidade de Pernambuco
Eligibility
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Participants both sex, male or female, aged 65 and older; are able to walk 10 meters without assistance; present subjective cognitive complaints and / or score less than 26 (of a total of 30 points) in Montreal Cognitive Assessment (MoCA); live independently in the community; and be able to read, write, speak and understand in the Portuguese language
Exclusion criteria
Exclusion criteria: Be engaged in structured exercise (e.g. aerobic, resistance or mind-body exercise classes) in the last three months; have had a clinical condition that interferes with exercise (e.g., angina pectoris); have had a previously diagnosed cardiovascular (e.g., stroke), neurodegenerative (e.g., Parkinson’s disease) or psychiatric (e.g., major depression) disease; have severe musculoskeletal or vestibular disorders; or are unable to complete the assessments or intervention due to inadequate vision and/or hearing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary 1: Fall incidence (self-reported number of falls documented prospectively on monthly falls calendars) from baseline to 6 months follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary 1: Fall related variables: Information about the place and date of the occurrence of falls, as well as context, symptoms before the fall and consequences (e.g. fall injuries/fractures, surgery, hospitalizations) will be collected along with falls calendars. ;Secondary 2: Changes in the fear of falling scores assessed through Fall Efficiency Scale International. This information will be gathered at baseline and after 6 months intervention.;Secondary 3: Improvements of functional performance and muscle strength from changes in scores, distance (meters), time (seconds) and percentages (%) in the following tests, respectively. Short physical performance battery; Six-minute walk test and 6-meter gait test (meters); time up & go (seconds); isokinetic muscle strength (%). This information will be computed before and after 6-months of intervention.;Secondary 4: Changes in Balance and Postural Control, this information will be computed before and after 6-months of intervention in the following tests: Mini Balance Evaluation Test score) and measurements of the center of pressure in biomechanics force platform amplitude (cm), velocity (cm/s) and standard deviation (cm).;Secondary 5: Changes in the scores of neurocognitive tests related to each cognitive domain. Global, Montreal Cognitive Assessment (MoCA); Executive functions, stroop test, trail making test part A & B, digit span backward & forward and verbal fluency (animal and naming). This information will be computed before and after 6-months of intervention.;Secondary 6: Changes in Blood-based biomarkers (brain-derived neurotrophic factor, tumor necrosis factor alpha, and interleukins). This information will be computed before and after 6 months of intervention. | — |
Countries
Brazil
Contacts
Public ContactMariana de Souza
Universidade Federal do Vale do São Francisco - UNIVASF
Outcome results
None listed