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Vomiting and tremor control after gallbladder surgery

Effect of the 5-HT3 antagonist on antiemetic control and post-anesthetic tremor in videocolecystectomy with total intravenous anesthesia with propofol-remifentanil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9b6486
Enrollment
Unknown
Registered
2020-02-20
Start date
2016-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholecystectomy in humans, prevention of vomiting and postoperative tremor, 5-HT3 antagonist, total intravenous anesthesia. Cholecystitis

Interventions

60 patients submitted to videocolecystectomy, distributed in 3 groups of equal number, and during perioperative treated with palonosetrone (0.125mg), or ondansetrone and dexamethasone (4mg) or dexamet
Drug
Procedure/surgery
E01.370.388.250.520
E03.155.308
D27.505.519.625.850.850.200

Sponsors

Universidade Federal de Uberlandia
Lead Sponsor
Universidade Federal de Uberlandia
Collaborator

Eligibility

Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 70 years; physical status ASA 1 or 2; elective surgery; upper abdominal laparoscopy; general intravenous anesthesia; analysis of the QTc interval on the electrocardiogram

Exclusion criteria

Exclusion criteria: History of hypersensitivity or contraindication to the use of the 5-HT3 antagonist. Intellectual inability to cooperate with evaluation procedures. Pregnant patient. Use of any potentially antiemetic medication within less than 24 hours. Symptom of nausea or vomiting in the last 24 hours. Alcoholics. Drug users.

Design outcomes

Primary

MeasureTime frame
Control of nausea or vomiting and tremor in the first 24 postoperative hours, with the use of 5- HT3 antagonist during the video-cholecystomy procedure under total intravenous anesthesia.;Effective control of nausea or vomiting and tremor in the first 12 postoperative hours with the use of 5- HT3 antagonist during the video-cholecystomy procedure under total intravenous anesthesia.—

Secondary

MeasureTime frame
The Rhodes Scale, used to assess nausea or vomiting in the postoperative period, in 60 individuals who underwent the procedure of videocolecystomy under total intravenous anesthesia, was applied 12 and 24 hours after the end of surgery. The occurrence of tremor was investigated in the first 24 hours.—

Countries

Brazil

Contacts

Public ContactNeuber;Neuber Fonseca;Fonseca

Universidade Federal de Uberlandia;Universidade Federal de Uberlandia

neubermf@gmail.com;neubermf@gmail.com+55-034-32258604;+55-034-999712022

Outcome results

None listed

Source: REBEC (via WHO ICTRP)