Morbidly obese patients undergoing bariatric surgery
Conditions
Interventions
Participants will be evaluated preoperatively by means of lung function, maximal capacity by means of cardiopulmonary exercise testing and submaximal exercise capacity by means of 6 minute walking tes
Other
E02.331.800
G11.427.590.530.698.277
Sponsors
Universidade Federal de São Carlos
Universidade Federal de São Carlos
Eligibility
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: This research will include obese (BMI 35 kg / m2) or morbidly obese (BMI 40 kg / m2) for at least three years or more without positive results to conventional treatments (pharmacological or not) aged 20 to 45 years will undergo surgery of Gastric Bypass (CBG). Patients with BMI> 30 kg / m2 may also be included according to medical team decision regarding the presence of important comorbidities indicated by Brazilian Bariatric Consensus.
Exclusion criteria
Exclusion criteria: Exclusion criteria are volunteers with orthopedic or neurological impairments that unable participation in an exercise program; myocardial infarction (within the beginning of the six-month study period); implanted pacemaker or any metallic synthesis; unstable angina; chronic disorders of the heart rhythm; moderate or severe valvular heart disease; consistent story of heart disease; uncontrolled hypertension; uncontrolled diabetes mellitus and / or insulin-dependent; beta-blocker users; postmenopausal women and participation in a regular program of physical activity at baseline. It will be also excluded from the present study any COPD volunteers or patients presenting other respiratory diseases or who present any contraindication to cardiopulmonary exercise test or condition that may limit the performance of the functional tests; distal artery diseases; inflammatory diseases; kidney diseases; and liver diseases with documented diabetic neuropathy; cognitive impairment; difficulty in understanding and / or adherence to study procedures; reported using illicit drugs and pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement in body composition (lean mass and fat mass ) by means of its measurement by bioimpedance scale (InBody 720) and dual energy X-ray absorptiometry data (DXA) , waiting for a free reduce of BMI and % fat and reduce by at least one degree of obesity classification.;Functional performance of submaximal tests (increased distance and / or the number of steps ascended) measured by the 6- minute walk test and the 2 -minute step test respectively, waiting a minimum increase of 25 m in walk and four steps as well the measure of oxigen uptake expecting an increase at least 20-30%.;Increase in strength and reduced quadriceps` fatigue through Isokinetic BIODEX SYSTEM , Biodex Multi -Joint System 2 Model BIODEX MEDICAL SYSTEM Inc., Biodex Software version. 4.5, waiting maintenance or increase of at least 5% in muscular strength and endurance. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of blood inflammatory markers measured by ELISA (Enzyme -Linked Immuno Sorbent Assay) with serum measurements performed in duplicate , reduce of metabolic profile measured by blood glucose, fasting insulin and consequent quantification of insulin resistance by the Homeostasis Model method Assessment (HOMA -IR ), hoping to reach normal values in accordance with the laboratory references.;In relation to flow-mediated vasodilation is expected to compare its response pre and post maximal exercise and submaximal test in obese people and identify whether there is a sex - dependent factor. It is expected only to study their behavior, because there is no normal values referenced for this population. | — |
Countries
Brazil
Contacts
Public ContactAudrey Silva
Universidade Federal de São Carlos - Departamento de Fisioterapia
Outcome results
None listed