Mucositis
Conditions
Interventions
This is a longitudinal clinical study with long-term follow-up. One hundred individuals who meet the eligibility criteria and present with diseases around dental implants will be included. Participant
bacterial plaque control
supragingival scaling with specific manual instruments (plastic curettes for implants) and ultrasonic device on teeth
tooth polishing with rubber cup and non-abrasive paste
air-polishing with sodium bicarbonate. Participants in the MU group will receive only non-surgical therapy if they have 2 millimeters or more of keratinized mucosa. If they have less than 2 millimeter
Sponsors
Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro
Universidade do Estado do Rio de Janeiro
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Individuals over 18 years of age; both genders; non-smokers; systemically healthy or medically controlled; partially edentulous, with at least two osseointegrated implants presenting peri-implant disease (peri-implant mucositis or peri-implantitis); with implant-supported prostheses in function for at least six months
Exclusion criteria
Exclusion criteria: Individuals who received periodontal or peri-implant treatment up to six months prior to the start of the study; pregnant or breastfeeding patients; smokers; individuals who used antibiotics and/or anti-inflammatory drugs in the past three months; those who used antiresorptive medications in the past two years; or who underwent radiotherapy, chemotherapy, or iodine therapy in the past two years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the association between peri-implant clinical parameters and the immunological activity of partially edentulous patients with peri-implant disease, before and after treatment, through the analysis of saliva samples, peri-implant crevicular fluid, and clinical and radiographic examinations. Variations in inflammatory cytokine levels and local clinical conditions, including probing depth, clinical attachment level, presence of plaque, bleeding on probing, suppuration, and periapical radiographic changes, will be observed, comparing data obtained at baseline and after two years of follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the immunological response between the peri-implant mucositis and peri-implantitis groups after two years of follow-up, using the analysis of inflammatory biomarkers in the peri-implant crevicular fluid and saliva;To compare the clinical results obtained with the different treatment modalities applied to patients with peri-implant disease, verified through clinical and radiographic evaluation of peri-implant parameters. Reductions in probing depth, bleeding on probing, and the presence of suppuration and plaque will be observed based on measurements taken before and after treatment, over the two-year follow-up period;To evaluate the expression of cytokines in the granulation tissue of patients with peri-implantitis and associate these findings with the results obtained in peri-implant crevicular fluid and saliva samples, through laboratory analysis of inflammatory biomarkers | — |
Countries
Brazil
Contacts
Public ContactLíssya Gonçalves
Universidade do Estado do Rio de Janeiro
Outcome results
None listed