Comparison between Custodiol, del Nido and del Nido modified cardioplegic solutions in myocardial protection with tissue and laboratory analysis during cardiopulmonary bypass of adult patients undergoing cardiac surgery. Heart Arrest, Induced
Conditions
Interventions
Ninety patients will be randomized to receive the solutions of del Nido, del Nido modified with
ringer lactate or Brestschneider during cardiopulmonary bypass, 30 for each group. An arterial
blood sam
Sponsors
Hospital Nossa Senhora da Conceição
Hospital Nossa Senhora da Conceição
Eligibility
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: All patients who underwent valve replacement surgery or myocardial revascularization with cardiopulmonary bypass at Hospital Nossa Senhora da Conceição, Porto Alegre, aged 18 years or over, in accordance with the Free and Informed Consent Form (Annex B), as Resolution 196/6, of June 13, 1988, of the National Health Council
Exclusion criteria
Exclusion criteria: Previous cardiac surgery; Chronic renal failure (serum creatinine greater than 1.5 mg/dL); Serious psychiatric illness; Urgency or emergency; Multiple surgeries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to assess myocardial protection between the 3 cardioplegic solutions through an anatomopathological examination of the epicardium for the analysis of cellular structural changes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessments of additional myocardial protection measures: ventricular fibrillation after opening the aortic clamp, changes in the postoperative ejection fraction, length of time using vasopressors or inotropic solutions and the need for hemodynamic support with an intra-aortic balloon.;Intraoperative results: total cardioplegia volume and number of doses, total aortic clamp time and extra-corporeal circulation.;Clinical outcomes: length of stay in the intensive care unit, incidence of postoperative atrial fibrillation or flutter, AMI, mortality and transfusions of blood products.;Comparisons between cardioplegic solutions regarding the prediction of major cardiovascular events in adult patients undergoing cardiac surgery.;Compare the cost-effectiveness ratio between the solutions.;Assessments myocardial protection through the serum levels of cardiac enzymes (CK, CK-MB and troponin)in the immediate postoperative period and 12 and 24 hours after the end of pulmonary bypass. | — |
Countries
Brazil
Contacts
Public ContactKathize Lira
Outcome results
None listed