Reduction of cardiovascular disease risk
Conditions
Interventions
Crossover study of dietary intervention in breakfast. 80 overweight adults with at least one more cardiovascular risk factor underwent two interventions in breakfasts, with a 4-week duration and 2-wee
Dietary supplement
Other
Sponsors
Faculdade de Saúde Pública, Universidade de São Paulo
Faculdade de Saúde Pública, Universidade de São Paulo
Eligibility
Age
35 Years to 69 Years
Inclusion criteria
Inclusion criteria: Both sexes, aged between 35 and 69 years Body mass index between 25 and 40 kg / m2 with at least one of the following criteria: triglycerides above 150 mg/dl; total cholesterol above 230 mg/dL or LDL-C above 100 mg/dl or plasma fasting glucose between 100 and 124 mg/dl.
Exclusion criteria
Exclusion criteria: live outside the city of São Paulo; pregnant women; patients with neurological problems or severe psychiatric diseases; use of anti-obesity medication; individuals with cancer, communicable and rheumatic diseases, liver or kidney failure, thyroid dysfunction untreated; a change of more than 5% of body weight within the last six months; performing some type of diet or modifications to the usual eating pattern.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in mean LDL plasma cholesterol (mg/dl) of, at least, 10% in relation to baseline values after 4 weeks of "Mediterranized" breakfast and maintenance of values after 4 weeks of Brazilian breakfast.;No differences were observed in plasma LDL cholesterol concentrations before and after "Mediterranized" or Brazilian breakfasts. The values were maintained throughout the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reductions of at least 10% in the concentrations of glucose and triglycerides are expected as well as similar increases in HDL concentrations and 10% reduction in insulin and pro-inflammatory markers (C-reactive protein, adiponectin, interleukin 1 beta, 6, 8:17 , interferon-gamma and monocyte chemoattractant protein 1, alpha tumor necrosis factor, E-selectin, fibrinogen) and the expression of genes after Mediterranized breakfast. It is expected the manteinance of values after Brazilian breakfast. The variables concentrations will be assessed by standard methods: glucose oxidase for glucose, colorimetric-enzymatic method for cholesterol and triglycerides and ELISA kits for insulin and inflammatory markers. Differences will be established by finding reductions or increases of at least 10% compared to pre-intervention values.;After 4 weeks of intervention "Mediterranized" breakfast it was observed a significant increase in HDL concentrations by 5% and reductions in c-reactive protein concentrations, interleukin-8 and monocyte chemoattractant protein by 10%. After Brazilian breakfast there was an increase of at least 25% in markers interleukin 1 beta, 6, 8 and 17 Interferon-Gamma, tumor necrosis factor alpha and selectin. | — |
Countries
Brazil
Contacts
Public ContactMilena ;Sandra Monfort Pires;Gouvea Ferreira Vivolo
Faculdade de Saúde Pública, Universidade de São Paulo;Faculdade de Saúde Pública, Universidade de São Paulo
Outcome results
None listed