Obstructive sleep apnea
Conditions
Interventions
High intensity interval group (HIIT)
25 patients will be assigned to HIIT group.
After warm-up, HIIT will be performed with 5 cycles of 4 min of walking or running between 85% and 90% of maximal heart
Other
G11.427.410.698.277.311.250
Sponsors
Universidade de Pernambuco
Universidade de Pernambuco
Pronto Socorro Cardiológico de Pernambuco
Eligibility
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Men and women; obstructive sleep apnea (OSA) moderate to severe (apnea-hypopnea index greater than 15 events / hour); diagnosed by nocturnal polysomnography; between 18 and 75 years old; overweight or obese; sedentary; taking stable doses of medication; not having previous treatment for OSA; medical authorization to practice physical activity
Exclusion criteria
Exclusion criteria: Cardiovascular; pulmonary or metabolic disease; resistant hypertension (159/99 mmHg with more than three drugs); pregnant or unable to exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea-hypopnea index higher than 15 events per hour verified by full polysomnography evaluated pre and post 12 weeks of treatment. ;Sleep quality assessed by the Pittsburg sleep quality index evaluated pre and post 12 weeks of treatment. ;Daytime sleepiness assessed by the Epworth Sleepiness Scale evaluated pre and post 12 weeks of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ambulatory blood pressure assessed by ambulatory blood pressure monitoring for 24 hours. The central arterial blood pressure pressure measurement will be performed by analysis of the radial artery pulse wave through the aplanation tonometry technique, which will be performed in both arms. The office blood pressure measurements will be determined by the result of the average of 2 readings of systolic (SBP) and diastolic blood pressure (DBP) obtained in 5 minute intervals using a validated and previously calibrated automatic device.;Central arterial stiffness will be obtained from the evaluation of the pulse wave velocity following the guidelines of the Clinical Application of Arterial Stiffness, Task Force III. For that, the technique of aplanation tonometry will be used. The distance traveled by the pulse wave will be calculated by subtracting the most distal and the most proximal distance.;Autonomic modulation of the cardiovascular system will be evaluated by the technique of heart rate variability (HRV). To do so, after at least 10 minutes of rest, patients will remain lying down for 10 minutes, during which RR intervals will be recorded, using a valid heart rate monitor for this function | — |
Countries
Brazil
Contacts
Public ContactOzeas Lins-Filho
Programa de Pós Graduação em Ciências da Saúde da Universidade de Pernambuco
Outcome results
None listed