Cognitive Dysfunction Cognition
Conditions
Interventions
This study consists of a quasi-experimental, longitudinal, interventional clinical trial conducted with long-lived older adults of both sexes receiving care through the Brazilian Unified Health System
Sponsors
Universidade do extremo sul catarinense - UNESC
Universidade do extremo sul catarinense - UNESC
Eligibility
Age
80 Years to No maximum
Inclusion criteria
Inclusion criteria: Volunteers aged 80 or older; individuals of both sexes; ability to move independently or with assistance; must have medical clearance to participate in physical exercise
Exclusion criteria
Exclusion criteria: Having a diagnosis of Alzheimer's disease (AD); previous history of neurological and/or psychiatric diseases, traumatic brain injury with loss of consciousness for more than 30 minutes; chronic exposure to neurotoxic substances in the head and neck region (chemotherapy or radiotherapy treatments); use/abuse of neurotoxic chemicals or alcoholism; continuous use of medications that interfere with cognition; use of a pacemaker or metal plates in the head or neck region; decompensated systemic diseases (diabetes mellitus, heart disease, renal or hepatic insufficiency, among others). uncorrected motor, visual or auditory impairment. claustrophobia that would prevent magnetic resonance imaging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cognitive function, assessed using the Mini-Mental State Examination (MMSE). It is expected that participants in the intervention group will show improved Mini-Mental State Examination (MMSE) scores after 24 weeks compared with those in the control group. Cognitive function will be measured using Mini-Mental State Examination (MMSE) scores obtained at baseline and post-intervention (24 weeks), and the primary outcome will be the change in these scores over the follow-up period | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional physical fitness, assessed using the Senior Fitness Test battery (Fullerton Protocol). Upper and lower limb muscle strength, aerobic endurance, flexibility, and dynamic balance will be measured at baseline and post-intervention (24 weeks). The outcome will be defined as the variation in results obtained for each physical fitness component over the follow-up period, as well as the association of these changes with the changes observed in cognitive function;Cerebral neurostructural parameters assessed via structural magnetic resonance imaging (MRI) with volumetric analysis. Hippocampal volume and other cerebral volumetric measurements obtained through structural MRI will be analyzed. Assessments will be conducted at baseline and post-intervention (24 weeks). The study outcomes will consider the change in these measurements over the follow-up period and the differences observed between the intervention and control groups. Additionally, a qualitative analysis of medial temporal lobe atrophy will be performed using the Medial Temporal Atrophy (MTA) scale. The MTA scale score will be considered a complementary qualitative variable, with an analysis of its distribution and change over time across the groups;Serum concentration of the myokine irisin will be assessed using the Enzyme-Linked Immunosorbent Assay (ELISA ). Measurements will be performed at baseline and post-intervention (24 weeks). The outcome will be defined as the change in irisin levels over the follow-up period, as well as their association with changes in cognitive function;Psychological resilience, assessed using the Connor-Davidson Resilience Scale (CD-RISC). Assessments will be conducted at baseline and post-intervention (24 weeks). The outcome measures will be the change in the Connor-Davidson Resilience Scale (CD-RISC). scores over the follow-up period and the differences observed between the intervention and control groups;Symptoms of anxiety and depression, assessed using the Geriatric D | — |
Countries
BR
Contacts
Public ContactJosiane Budni
Universidade do Extremo Sul Catarinense
Outcome results
None listed