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How Exercise and a Low-Calorie Diet can improve breathing during effort in people with Metabolic Syndrome

Effect of Physical Training and Hypocaloric Diet on ventilatory efficiency during progressive exercise in patients with Metabolic Syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-96hpf7j
Enrollment
Unknown
Registered
2025-09-09
Start date
2023-01-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic syndrome

Interventions

43 adult women, aged 18 to 50, diagnosed with Metabolic Syndrome according to the National Cholesterol Education Program, Adult Treatment Panel III (NCEP, ATP-III) criteria, will be evaluated. Volunte
I02.233.543

Sponsors

Universidade Federal de São Paulo
Lead Sponsor
Universidade Santa Cecília
Collaborator

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Sedentary women; between 18 and 50 years old; with Metabolic Syndrome, according to the National Cholesterol Education Program, Adult Treatment Panel III criteria.

Exclusion criteria

Exclusion criteria: Women enrolled in other physical training programs; undergoing dietary treatment; smokers; with a history of alcohol consumption; with cardiovascular disease or a metabolic condition beyond those already included in Metabolic Syndrome; with less than 75% participation in physical training sessions; who experience changes in medication during the experimental protocol.

Design outcomes

Primary

MeasureTime frame
Expected outcome 1: It is expected to find at least a 20% improvement in the oxygen uptake efficiency slope after the experimental period compared to the pre-experimental moment, as assessed by the cardiopulmonary exercise test.;Outcome found 1: An increase of 86.7% was observed in the slope of oxygen consumption efficiency after the experimental period when compared to the pre-experimental period, assessed through the cardiopulmonary stress test.

Secondary

MeasureTime frame
Expected outcome 2: It is expected to find at least a 20% improvement in the oxygen uptake and workload relationship after the experimental period compared to the pre-experimental moment, as assessed by the cardiopulmonary exercise test.;Expected outcome 3: It is expected to find an improvement of at least 20% in maximum oxygen consumption during maximum progressive physical exercise after the experimental period when compared to the pre-experimental moment, assessed through the cardiopulmonary stress test.;Expected outcome 4: It is expected to find at least a 10% decrease in body mass after the experimental period when compared to the pre-experimental time.;Expected outcome 5: It is expected to find at least a 10% decrease in body mass index after the experimental period when compared to the pre-experimental time.;Expected outcome 6: It is expected to find at least a 20% decrease in body fat percentage after the experimental period when compared to the pre-experimental time.;Expected outcome 7: It is expected to find at least a 5 mmHg decrease in blood pressure after the experimental period when compared to the pre-experimental time.;Expected outcome 8: It is expected to find a decrease of at least 10% in fasting blood glucose after the experimental period when compared to the pre-experimental period.;Outcome found 2: An 86% increase was observed in the oxygen consumption and workload relationship after the experimental period when compared to the pre-experimental period, assessed through the cardiopulmonary stress test.;Outcome found 3: A 14% improvement in maximum oxygen consumption was found during maximum progressive physical exercise after the experimental period when compared to the pre-experimental period, assessed through the cardiopulmonary exercise test.;Outcome found 4: A decrease of at least 9.7% in body mass was observed after the experimental period when compared to the pre-experimental period.;Outcome found 5: A 9.4% decrease in body mass index was o

Countries

Brazil

Contacts

Public ContactAlessandra Medeiros

Universidade Federal de São Paulo

a.medeiros@unifesp.br+55(11)981798528

Outcome results

None listed

Source: REBEC (via WHO ICTRP)