Unspecified septicemia, Septic shock
Conditions
Interventions
After adequate volume resuscitation patients will be randomized into two groups (I and II), as follows:
Group I (standard) - Noradrenaline in progressive doses until achieving hemodynamic stability. (
C23.550.470.790.500
HP3.073.414
Sponsors
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo
Faculdade de Medicina de São José do Rio Preto
Eligibility
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 85 years; of both sexes; who were victims of septic shock of any origin in the first 72 hours of evolution; in use of noradrenaline larger dose 0.3 mcg/kg/min; vasopressin dose 0,05 ui/min; and using mechanical ventilation
Exclusion criteria
Exclusion criteria: Pregnant patients (negative pregnancy test in female patients of childbearing age); in use of serotonergic agents; previous septic shock in the same hospital; use of immunosuppressive therapy; CD4 smaller 200 cells/mm3; neutrophils smaller 500 mm3; palliative care; imminent or inevitable death during hospitalization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A reduction in the dose of norepinephrine and vasopressin is expected in a patient with septic shock in the standard treatment plus methylene blue group compared to the standard treatment group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality reduction within 30 days | — |
Countries
Brazil
Contacts
Public ContactFábio Silva
Outcome results
None listed