Hyperphosphatemia
Conditions
Interventions
The study consisted of 78 hemodialysis patients, of both sexes, in continuous use of sevelamer hydrochloride. The individuals were divided into three groups with 26 patients each, being they the Inter
Other
SP6.026
D02.092.782.634
Sponsors
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Eligibility
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients on hemodialysis for at least 6 months and who underwent a dialysis regimen at three times a week with a duration of four hours per session; age range greater than or equal to 18 years; literate or had literate carer; phosphate binder use for at least 12 weeks; parathyroid hormone less than 800pg/mL; signed the written informed consent form
Exclusion criteria
Exclusion criteria: Patients who missed more than one hemodialysis session per month; patients in use of anti-inflammatory hormones; patients with neoplasias or active infectious diseases; patients with indication of use of calcium carbonate as phosphate binder and who had no indication of sevelamer hydrochloride use; hypophosphatemic patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of serum phosphorus levels from a 15% improvement in the control response rate for group A and a 20% improvement in the control response rate for group B after the intervention;Maintenance of serum phosphorus levels when observing pre and post intervention measurements in groups A and B | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in 17% of phosphorus intake by means of analysis of phosphorus intake during before and after intervention through 3-d food record;Maintenance of nutritional status by observing the means of body mass index greater than or equal to 18 Kg/m2 and serum levels of albumin greater than 3,8 g/dL, creatinine greater than 9 mg/dL, total cholesterol between 100 and 200 mg/dL and transferrin between 250 and 450 mg/dL during the interval before and after intervention;Reduction in 25% of pill burden of sevelamer hydrochloride consumed during the interval before and after intervention | — |
Countries
Brazil
Contacts
Public ContactJosé Costa
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Outcome results
None listed