Gonarthrosis. Nerve block. Ropivacaine. Dexamethasone
Conditions
Interventions
This is a randomized, controlled, triple-blind clinical trial that will include patients aged between 18 and 80 years, with a diagnosis of symptomatic knee osteoarthritis that is refractory to convent
Sponsors
Programa de Pós-Graduação em Farmacologia
Universidade Federal de Santa Catarina
Eligibility
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 80 years, diagnosed with symptomatic knee osteoarthritis refractory to conventional analgesics and with an indication for total knee arthroplasty (TKA), but unable to undergo the procedure either due to clinical contraindications or prolonged waiting times within the Unified Health System, will be included in this study. Furthermore, only patients who voluntarily agree to participate and sign the informed consent form (ICF) will be considered
Exclusion criteria
Exclusion criteria: Patients with mild or asymptomatic osteoarthritis, defined according to the Kellgren Lawrence Criteria, will be excluded from this study; those who undergo follow up at the algology clinic (due to the possibility of multiple interventions that may interfere with the result); those with neurological deficit (sensory or motor) in the limb; those with signs of infection at the puncture site; those with a history of coagulopathies; those with intellectual deficits in responding to the questionnaires applied
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to observe a reduction in pain using the Visual Analog Pain Scale, measured before the intervention and repeated at one hour, twenty-four hours, and four weeks after the infiltration between the popliteal artery and the knee capsule with local anesthetic compared to saline solution, with this difference serving as the basis for the sample size calculation and considered the primary parameter for determining the analgesic effect of the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to observe an improvement in knee function assessed through the sit-to-stand test, an increase in muscle strength of the groups innervated by the sciatic and femoral nerves measured by dynamometer, as well as changes in pain thresholds evaluated using a pressure algometer at different points of the joint, and an improvement in overall participant satisfaction measured by a structured questionnaire applied twenty-four hours after the intervention | — |
Countries
Brazil
Contacts
Public ContactJoana Martins
Universidade Federal de Santa Catarina
Outcome results
None listed