Unspecified rheumatoid arthritis
Conditions
Interventions
A cross-sectional observational study in which 150 patients diagnosed with rheumatoid arthritis who had previously received the yellow fever vaccine will be submitted to blood collection for neutraliz
Other
E01.370.225.500.363.342
Sponsors
Centro de Pesquisas René Rachou- FIOCRUZ
Centro de Pesquisas René Rachou- FIOCRUZ
Eligibility
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Be over 18 years of age; to present a diagnosis of Rheumatoid Arthritis; being in use of immunosuppressants; be accompanied at the University Hospital of Brasília; have previously been vaccinated against yellow fever
Exclusion criteria
Exclusion criteria: Pregnant women ; organic mental illness; carriers of other autoimmune diseases or neoplasms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: A lower vaccine protection in the study group (rheumatoid arthritis using immunosuppressants) was verified by the antigen-specific B and T lymphocyte profile, analyzed by flow cytometry of the peripheral mononuclear cell culture;Expected outcome 2: The study group (rheumatoid arthritis using immunosuppressants) has a lower amount of neutralizing antibodies, verified by the PRNT (plaque reduction neutralization test) method, in comparison to the control group | — |
Secondary
| Measure | Time frame |
|---|---|
| Less vaccine protection in the study group (rheumatoid arthritis using immunosuppressive drugs) verified by the signature profile of intracytoplasmic cytokines, analyzed by flow cytometry of the peripheral mononuclear cell culture | — |
Countries
Brazil
Contacts
Public ContactClarissa ;Clarissa Ferreira;Ferreira
Hospital Universitário de Brasilia;Hospital Universitário de Brasilia
Outcome results
None listed