Cirrhosis
Conditions
Interventions
Three different groups: GF, GCA e GC.
Group GC: 15 subjects, tests and measurements of the study, with no intervention. every 15 days, a clinical apointment for evaluation will be scheduled in Hospita
Behavioural
E02.779.474
Sponsors
Fundação Universidade de Caxias do Sul - FUCS/RS
Universidade de Caxias do Sul
Eligibility
Age
18 Years to 72 Years
Inclusion criteria
Inclusion criteria: Studied population will be of men and women with cirrhosis. To be a part of the sample, the patients will have to be in the inclusion criteria: age between 18 and 72 years, BMI 18.5-34.9, with no obesity or grade I (WHO). No force training prior to the study for 6 months, no current use of alcohol or tobacco for 6 months, if the patient is hypertensive it need to be controlled for inclusion, compensated cirrhosis Child A or B with histological documentation or through the association of laboratorial data ans image studies suggesting cirrhosis.
Exclusion criteria
Exclusion criteria: Exclusion criteria will be the following co-morbidities: decompensated diabetes, severe heart failure that prohibits exercise, periphereal amputations, chronic renal failure; clinical depression; muscular disease that physically impossibilits force training, decompensated cirrhosis, hence these patients cannot do heavy exercise. Regarding cirrhosis, exclusion criteria will be: decompensated cirrhosis, previous variceal bleeding without endoscopically confirmed erradication of esophageal varices, Child C, large varices, presence of ascitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Combined outcome of clinical complications (all-cause hospital admission, hepatic encephalopathy and all-cause death) measured though a brief interview each evaluation, measured dicotomically as yes-no | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of muscle quality and functional capacity after a 6-month intervention, measured through 6-minute walk test and muscle ultrasonography; Improvement of liver-disease scores: Child-Pugh, MELD, MELD-Na in at least one point previous and after the intervention; Improvement of mean leves of hemoglobin pre and post intervention; Improvement of mean leves of sodium pre and post intervention; Improvement of mean leves of INR pre and post intervention; Improvement of mean leves of albumin pre and post intervention; Improvement of mean leves of reacite C protein pre and post intervention; Improvement of mean leves of total bilirubin pre and post intervention; Improvement of mean leves of sarcopenia pre and post intervention measured through Computerized tomography; Measurement of quality of life through questionaires SF-36, EICF and CLDQ validated for portuguese pre and post intervention; Leves of force in femoral quadriceps pre and post intervention. | — |
Countries
Brazil
Contacts
Public ContactJonathan Soldera
Universidade de Caxias do Sul
Outcome results
None listed