Chronic Hepatitis C, Endothelial Dysfunction, Atherosclerosis
Conditions
Interventions
Experimental group: 35 participants received folinic acid (FA) five (5) milligrams (mg) orally, once daily in the morning, for four weeks. The control group (34 participants) received placebo. Partici
Dietary supplement
Other
HP3.073.433.101
Sponsors
Fabio Lopes Pedro
Fabio Lopes Pedro
Eligibility
Age
18 Years to 49 Years
Inclusion criteria
Inclusion criteria: Monoinfected patients by with HIV; or HCV-HIV co-infected; using antiretroviral therapy; who signed an consent form.
Exclusion criteria
Exclusion criteria: history of diabetes mellitus; acute myocardial infarction; renal insufficiency (creatinine current> 1.5); stroke; clinical signs and / or laboratory evidence of liver cirrhosis (ascites, hepatic encephalopathy present or recent upper gastrointestinal bleeding, esophageal varices present, liver ultrasound with signs suggestive of cirrhosis, biopsy Metavir F4); current pregnancy; recent use (last 30 days) of: statins, fibrates, hormone replacement therapy, sulfonamides (sulfamethoxazole, sulfadiazine), vitamin supplements, or similar of folinic acid and / or folic acid; Individuals with restriction or inability to understand and decide for their participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the vascular response of the brachial artery during reactive hyperemia, as measured by Doppler ultrasound before and after the intervention. The variation of at least 20% of the flow is considered positive outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are changes in biochemical and hemodynamic variables at baseline and after interventions. Laboratory analysis (serum): homocysteine,folic acid, vitamin B12, creatinine, fasting glucose, cholesterol, (total, high and low density), triglycerides. Will be measured blood pressure, heart rate, weight, height. | — |
Countries
Brazil
Contacts
Public ContactFabio ;Sandra Lopes Pedro;Fuchs
Hospital Universitario de Santa Maria;Hospital de Clinicas de Porto Alegre
Outcome results
None listed