Coronavirus infections of unspecified location
Conditions
Interventions
Patients will be randomized into two groups in a 1:1 ratio through a four-patient block randomization program.
Intervention group: 24 patients (both gender and aged 18 years or above) diagnosed with C
Sponsors
Hospital Risoleta Tolentino Neves
Ecotec Equipamentos e Sistemas Eirelli
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over 18 years of age; diagnosis confirmed by laboratory tests or computed tomography (CT) of the chest compatible with COVID-19; oxygen saturation below 93% in ambient air; respiratory frequency greater than or equal to 24 resp / min; without a significant commitment from other bodies or systems.
Exclusion criteria
Exclusion criteria: Hemodynamic instability, defined by mean arterial pressure less than 60 mmHg; respiratory failure requiring intubation; blood levels of TGO/TGP greater than 5 times the upper limit of normal; several chronic kidney diseases in stage 4; kidney disease requiring dialysis, that is, with eGFR (Estimated Glomerular Filtration Rate) less than 30 mL/min; transition planned to another hospital, other than a place of study, within 72 hours; infection with the human immunodeficiency virus under highly active antiretroviral therapy (HAART); history of severe depression or attempted suicide or current suicidal ideation; contraindications related to the administration of hyperbaric oxygen: pregnancy; breast-feeding; untreated pneumothorax; use of adriblastine, cisplatin, doxorubicin and mafenide; topical use of iodine and / or petrolatum; advanced emphysema with CO2 retention; claustrophobia; other conditions identified by the hyperbarist team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the inpatient time; need for mechanical ventilation (intubation); mortality and incidence of serious adverse events. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate oximetry at admission and during hospitalization; time on days of supplemental oxygen use; number of days free from the need for supplemental oxygenation; time on days of non-invasive ventilation (NIV) use; time in days of use of invasive ventilation (orotracheal intubation); laboratory tests at admission and during hospitalization: hemoglobin, platelets, creatinine, leukocytes, electrolytes, prothrombin, glucose, bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin. | — |
Countries
Brazil
Contacts
Public ContactRogério;Túlio Noronha;Navarro
Hospital Risoleta Tolentino Neves;
Outcome results
None listed