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Memory and obesity: the impact of a calorie-restricted diet on neuroplasticity

Evaluation of adult hippocampal neuroplasticity in obesity: cognitive and biochemical impacts of a caloric restriction protocol, a randomized clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
REBEC
Registry ID
RBR-92s874h
Enrollment
Unknown
Registered
2024-12-03
Start date
2024-06-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

This is a randomized controlled parallel study. The study will involve two data collection moments, baseline and 12 weeks after the start of the intervention. The nutritional intervention of calorie r

Sponsors

Universidade Federal de Santa Catarina
Lead Sponsor
Universidade Federal de Santa Catarina
Collaborator

Eligibility

Age
21 Years to 50 Years

Inclusion criteria

Inclusion criteria: Individuals of both sexes; aged between 21 and 51 years; diagnosed with grade I and II obesity taking into account height and physical structure

Exclusion criteria

Exclusion criteria: Individuals who have liver disease with the exception of hepatic steatosis; kidney disease, cardiovascular disease, type 1 diabetes mellitus, fibromyalgia, cancer and epilepsy; uncontrolled depression; post-bariatric surgery; shift workers; women who are pregnant or lactating or who are planning and undergoing treatment to become pregnant; patients taking slimming drugs; a history of excessive alcohol use or substance abuse; individuals who have experienced significant weight loss in the last six months

Design outcomes

Primary

MeasureTime frame
We expect to find differences in pattern separation ability, recognition memory performance and BMI before and after the calorie restriction protocol

Secondary

MeasureTime frame
We expect to find differences in the biochemical analysis of inflammatory markers, BDNF, GLP-1, insulin and markers of insulin resistance

Countries

Brazil

Contacts

Public ContactPatricia Brocardo

Universidade Federal de Santa Catarina

patibrocardo@gmail.com+55(048)3721-4907

Outcome results

None listed

Source: REBEC (via WHO ICTRP)