Taste Disorders
Conditions
Interventions
This is a randomized, controlled, single-blind (patient-only) clinical trial with 5 arms. Each arm of the study will have 25 participants, except for the control group, which will consist of 15 indivi
(2) FBML without OT
(3) FBML SHAM/OT
(4) FBML SHAM without OT
(5) Healthy control group, who will not receive intervention and from whom only a saliva sample will be collected and a taste identification test (Mueller Test) and olfactory alterations test (UPSIT)
(2) FBML without TO
(3) FBML SHAM/TO
(4) FBML SHAM without TO. The intervention for the FBML Sham group consists of simulating the application of laser light without the device being activated. After the 6th week of therapy, if patients
Sponsors
Universidade Federal do Sul da Bahia
Universidade Federal do Sul da Bahia
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Individuals over 18 years of age; emancipated individuals aged 16 to 18; both sexes; who have been diagnosed with COVID-19 more than 30 days prior; and who present with altered taste and/or smell after the illness. For the control group: individuals over 18 years of age; or emancipated individuals aged 16 to 18; both sexes; who have been vaccinated against COVID-19, regardless of the vaccination schedule; and have not had the disease
Exclusion criteria
Exclusion criteria: Individuals with diabetes and/or hypertension; those who have undergone surgery on the central nervous system and those who have suffered trauma or strokes; individuals diagnosed with neurological diseases such as Alzheimer's or Parkinson's; due to the COVID-19 pandemic, it is imperative to exclude from the sample individuals, from both groups, who present signs and symptoms such as cough, fever, malaise, difficulty breathing, or any other respiratory symptoms that may suggest symptomatic manifestation of COVID-19 in the 14 days prior to sample collection; the same criteria apply to individuals in the control group; participants who cannot use resources that allow for remote consultations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Photobiomodulation with laser, with or without olfactory training, is expected to accelerate the recovery of taste and smell abilities in research participants. The evaluation of these outcomes will be measured by taste and smell tests. ;Finding outcome 1: Laser photobiomodulation improves the clinical condition of patients with ageusia/dysgeusia associated with SARS-CoV-2 infection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 1: To analyze the role of laser photobiomodulation in patients with ageusia/dysgeusia associated with SARS-CoV-2 infection.;Expected outcome 2: To evaluate the inflammatory profile of saliva and nasal fluid in individuals with ageusia and/or anosmia after COVID-19 infection. ;Finding outcome 2: There are differences in the saliva of individuals who underwent laser photobiomodulation and who experienced recovery of the sense of smell. Nasal fluid was not collected. | — |
Countries
BR
Contacts
Public ContactHayana Lima
Universidade Federal do Sul da Bahia
Outcome results
None listed