Pain, Postoperative
Conditions
Interventions
The research project will consist of a randomized, triple-blind, split-mouth clinical study and will be submitted to the Local Research Ethics Committee, in which all volunteers, thirty-six participan
ozone oil (administration of six hundred milliequivalents of ozonized oil via subperiosteal route)
and control (without administration of therapy) administered in the immediate postoperative period, two and seven days. Surgical extraction of third molars with osteotomy, using local anesthetic mepiv
E06.892
Sponsors
Universidade Estadual Paulista Júlio de Mesquita Filho
Faculdade de Odontologia de Araçatuba- FOA UNESP
Eligibility
Age
16 Years to 35 Years
Inclusion criteria
Inclusion criteria: Patients with favorable systemic and local health conditions; be between 16 and 35 years of age; both genders; with indication of tooth extraction of the lower third molars (elements 38 and 48), in position A or B and Pell & Gregory classification I or II, with at least 2/3 of the root formed
Exclusion criteria
Exclusion criteria: Mandibular third molars in position C and Pell & Gregory classification III; signs of local manifestations such as pericoronitis, cysts and odontogenic tumors associated or not with the third molar, trauma in the region, presence of infection or periodontal disease; patients with any systemic disease that interferes with the results of the procedure or who cannot use the drugs present in the study; presence of a history of hypersensitivity to drugs present in the study and to products used in the procedure, such as: 0.5% alcoholic chlorhexidine solution, 0.12% chlorhexidine digluconate solution and 2% mepivacaine hydrochloride solution with epinephrine 1:100,000; women who are menstruating, pregnant or breastfeeding during the study period; patients using medications to control psychiatric diseases, corticosteroids, estrogens and androgens
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinically compare the effectiveness of protocols in controlling postoperative symptoms (pain) using the visual analogue scale (VAS) as a method, as follows: a sheet will be provided with a 10cm straight line on which the patient will be instructed to mark a point between the extremes "no pain" and "unbearable pain | — |
Secondary
| Measure | Time frame |
|---|---|
| To analyze the concentration of salivary biomarkers indicating tissue inflammation: total protein (PT), acid phosphatase (FA), alkaline phosphatase (FAL), aspartate aminotransferase (AST), alanine aminotransferase (ALT) present in the saliva of patients in each experimental group in each analysis time through biochemical evaluation;To evaluate whether ozone therapy is effective in modulating oxidative stress based on the analysis of the biomarker of thiobarbituric acid reactive species (TBARS) | — |
Countries
Brazil
Contacts
Public ContactMonique da Costa
Faculdade de Odontologia de Araçatuba- FOA UNESP
Outcome results
None listed