Nutritional and metabolic diseases
Conditions
Interventions
Test group (n = 26): hypocaloric diet plan (- 500 kcal / day) including oral consumption of 15g of whole Brazil nuts
during eight weeks.
Control group (n = 26): hypocaloric diet plan (- 500 kcal / day) without nuts intake
during eight weeks.
The volunteers will be evaluated at the beginning and at the end of the intervention, fasting, in the laboratory. On the day of the evaluation, fasting blood and urine samples will
Other
Sponsors
Universidade Federal de Viçosa
Universidade Federal de Viçosa
Eligibility
Sex/Gender
Female
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: Adult women aged 20 to 55 years; excess body fat (equal or greater than 32%) and high waist circumference (equal or greater than 80 cm); overweight (BMI equal or greater than 27 kg/m2) associated with at least one more component of the Metabolic Syndrome, which means triglycerides equal or greater than 150 mg/dL, blood pressure equal or greater than 130 and/or 85 mmHg for systolic and diastolic pressures, respectively, or fasting glucose equal or greater than 100 mg / dL) or; obesity (BMI equal or greater than 30 kg/m2) regardless of the presence of the other components of the Metabolic Syndrome
Exclusion criteria
Exclusion criteria: Women younger than 20 years or older than 55 years; body fat percentage less than 32%; waist circumference less than 80 cm; BMI below 27 kg/m²; BMI between 27 and 30 kg/m², without the presence of any other component of metabolic synddrome, pregnant women, nursing mothers, or menopausal women; athletes; smokers; with a history of HIV, digestive alterations, hepatic or renal diseases, cardiovascular diseases, hypo or hyerthyroidism, cancer, inflammatory diseases and eating disorders; history of drug and/or alcohol abuse; aversion or allergy to nuts; infectious episode in the last month; use of anti-inflammatory drugs, corticosteroids, antibiotics and others that can affect appetite and energy metabolism; weight instability (5% of usual weight) in the last 3 months; daily consumption of nuts (greater than 5g for Brazil nuts and greater than 30 g/day for other nuts); alcohol consumption higher than 21 units (168g) per week; dental problems that interfere with chewing; consumption of vitamin, mineral and omega 3 supplements in tha last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in body weight and waist circumference by at least 5%, compared to control (hypocaloric diet free of nuts). All analyzes will be performed at the end of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase of at least 5% in the postprandial metabolic rate (evaluated by calorimetry), in comparison to the control (hypocaloric diet without nuts). All analyzes will be performed at the end of the study.;Increase in selenoprotein gene expression and reduction in oxidative stress markers in plasma, compared to control (hypocaloric diet free of nuts). All analyzes will be performed at the end of the study.;Reduction in intestinal permeability and endotoxemia (measured by LPS in plasma), compared to control(hypocaloric diet free of nuts). All analyzes will be performed at the end of the study.;Increase in sirtuin 1 gene expression (SIRT 1), compared to control(hypocaloric diet free of nuts). All analyzes will be performed at the end of the study.;Decrease in pro-inflammatory markers (assessed by plasma markers: IL-6, CRP), and increase in anti-inflammatory markers (assessed by plasma markers: IL-10), compared to control (hypocaloric diet free of nuts). All analyzes will be performed at the end of the study.;Reduced appetite and increased satiety (assessed using Visual Analogue Scale questionnaires), contributing to a reduction in habitual food intake (assessed using food records), compared to control (hypocaloric diet free of nuts). All analyzes will be performed at the end of the study. | — |
Countries
Brazil
Contacts
Public ContactHelen;Josefina Hermsdorff;Bressan
Universidade Federal de Viçosa;Universidade Federal de Viçosa
Outcome results
None listed