Senility
Conditions
Interventions
The volunteers will be matched by muscle mass and randomly allocated in the 1: 1 ratio by a person not involved in the study in one of the following experimental groups: a) Frail elderly women with ex
b) Pre-frail elderly women with exercise (PE) (n=12)
c) Frail elderly control women (FC)(n=12)
d) Pre-frail elderly control women (PC) (n=12). Additionally, non-frail elderly women submitted to the same exclusion criteria will be recruited to form the control group (C) (n=12). The FE and PE gro
2) Rotation of the seated trunk
3) Lateral flexion of the seated trunk
4) Lateral arm elevation
5) Unilateral flexion of the lying hip, 6) adduction and horizontal abduction of the shoulders with adducted arms, 7) hip extension and knee flexion simultaneously in lateral decubitus
8) Standing calf extension supported on the wall.
G11.427.410.698.277
Sponsors
Faculdade de Educação Física da Unicamp
Faculdade de Educação Física da Unicamp
Eligibility
Sex/Gender
Female
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Women over 65 years old
Exclusion criteria
Exclusion criteria: Engaging in exercise programs in the six months preceding the beginning of the experimental design; consumption of nutritional supplements and anabolic steroids in the six months preceding the beginning of the experimental protocol; adherence to restrictive diets; nephropathies, hyper or hypothyroidism, cancer, or obstructive lung disease; untreated arterial hypertension; diabetes mellitus; body mass index greater than 35 kg / m2; smoker; cognitive impairment; any cardiovascular, neurological or musculoskeletal problem that makes physical exercise unfeasible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the serum metabolome, assessed by means of nuclear magnetic resonance spectroscopy. The metabolome is the set of metabolites identified in the sample, therefore, the occurrence and concentration of metabolites in millimolar (mM) will be checked. The metabolome is expected to be different between groups and to be altered by chronic exercise | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition will be assessed using dual-energy X-ray absorptiometry (DEXA). The relative (%) and absolute (kg) lean and fat mass will be determined. It is expected that body composition will change after exercise training, decreasing fat mass and increasing lean mass;Functional capacity will be assessed through the Timed Stand and Time Up and Go tests. The walking time and number of times it was possible to get up from a chair per unit of time will be determined. These parameters are expected to improve after exercise training;Muscle strength functional will be assessed through a handgrip dynamometer. The total load (kg) will be determined. It is expected that this parameter will improve after exercise training;Blood cytokines concentrations (pg/ml) will be assessed through an immunoassay test (ELISA) | — |
Countries
Brazil
Contacts
Public ContactDavi;Comitê de ética em Pesquisa De Santana;da Universidade Estadual de Campinas
Faculdade de Educação Física da Unicamp;Faculdade de Educação Física da Unicamp
Outcome results
None listed