Anesthetic Effect of Articaine 2% with Epinephrine 1: 200,000 with Sodium Bicarbonate in Maxilla Infiltration

Effect of Alkalinization of the 2% Articaine Hydrochloride Solution with Epinephrine 1: 200.000 on anesthetic efficiency in infiltration in the maxilla Crossover randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

REBEC

Registry ID

RBR-8yyzzz

Enrollment

Unknown

Registered

2020-05-18

Start date

2019-02-14

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Interventions

Test group: 42 healthy volunteers (men and women) will receive infiltrative anesthesia in the upper canine region with the Articaine hydrochloride solution 4% with Epinephrine 1: 200,000 in the first

Drug

Procedure/surgery

E03.155.141

SP4.011.097.105.074

D02.886.778.150

Eligibility

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Healthy individuals; age between 18 and 45 years; similar level of education, from incomplete third grade; previous experience of local anesthesia; absence of history of complications resulting from local anesthesia; presence of healthy maxillary incisors, canines and premolars

Exclusion criteria

Exclusion criteria: Pregnant women; infants; volunteers with systemic impairment that contraindicate anesthesia; volunteers who present a history of allergic reaction to any component of the anesthetic solutions used

Design outcomes

Primary

Measure	Time frame
to evaluate the alkalinization effect of Articaine hydrochloride solution 2% with epinephrine 1: 200,000 in infiltration of the maxilla.;to evaluate the alkalinization effect of Articaine hydrochloride solution 2% with epinephrine 1: 200,000 in infiltration of the maxilla.	—

Secondary

Measure	Time frame
To compare the effects of alkalinized 2% Articaine hydrochloride solutions with 1: 200,000 epinephrine and 4% Articaine with 1: 200,000 epinephrine on the anesthetic effectiveness in infiltration in maxillary canine region: ? Regarding the latency time ? Injection pain ? The duration of anesthesia in hard and soft tissues. ? pH;To compare the effects of alkalinized 2% Articaine hydrochloride solutions with 1: 200,000 epinephrine and 4% Articaine with 1: 200,000 epinephrine on the anesthetic effectiveness in infiltration in maxillary canine region: Regarding the latency time Injection pain The duration of anesthesia in hard and soft tissues. pH	—

Measure

Time frame

To compare the effects of alkalinized 2% Articaine hydrochloride solutions with 1: 200,000 epinephrine and 4% Articaine with 1: 200,000 epinephrine on the anesthetic effectiveness in infiltration in maxillary canine region: ? Regarding the latency time ? Injection pain ? The duration of anesthesia in hard and soft tissues. ? pH;To compare the effects of alkalinized 2% Articaine hydrochloride solutions with 1: 200,000 epinephrine and 4% Articaine with 1: 200,000 epinephrine on the anesthetic effectiveness in infiltration in maxillary canine region: Regarding the latency time Injection pain The duration of anesthesia in hard and soft tissues. pH

—

Countries

Brazil

Contacts

Public ContactVanessa Tavares da Silva Fontes

Universidade Federal de Sergipe

vanessa.tavares.se@gmail.com+55 079 999293385

Outcome results

None listed

Source: REBEC (via WHO ICTRP)