Evaluation of a brain stimulation technique for the treatment of people with cocaine dependence

Transcranial Magnetic Stimulation in the treatment of Cocaine Dependence: evaluation of efficacy in a clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

REBEC

Registry ID

RBR-8y6j7w3

Enrollment

Unknown

Registered

2025-07-01

Start date

2024-10-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety disorder

Interventions

Randomized, controlled, double-blind clinical trial with two parallel groups. Experimental group: 12 participants will receive sessions of repetitive Transcranial Magnetic Stimulation (rTMS) for 8 con

E02.319

Eligibility

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Being diagnosed with cocaine dependence according to the Diagnostic and Statistical Manual of Mental Disorders DSM-5 criteria. Age between 18 and 70 years. Undergoing treatment at the Psychosocial Care Center for Alcohol and Drugs CAPS AD for at least six months. Having stable use of psychotropic medications if applicable for at least three months prior to the start of the study. Both sexes

Exclusion criteria

Exclusion criteria: Have a history of electroconvulsive therapy (ECT). Brain implants. Stroke or traumatic brain injury in the last 12 months. Diagnosis of epilepsy. Diagnosis of brain malformations. Diagnosis of schizophrenia. Use of medications that interfere with cortical excitability. Hypersensitivity to magnetic stimuli

Design outcomes

Primary

Measure	Time frame
Expected outcome: reduction of cocaine craving, assessed by a standardized craving scale (Analog Craving Scale - AGG), comparing scores before and after the intervention with Transcranial Magnetic Stimulation (TMS) ;Found outcome: a mean reduction of 35% in cocaine craving scores was observed on the AGG scale after 8 weeks of Transcranial Magnetic Stimulation (TMS), compared to the control group, with statistically significant difference (p<0.05)	—

Measure

Time frame

Expected outcome: reduction of cocaine craving, assessed by a standardized craving scale (Analog Craving Scale - AGG), comparing scores before and after the intervention with Transcranial Magnetic Stimulation (TMS) ;Found outcome: a mean reduction of 35% in cocaine craving scores was observed on the AGG scale after 8 weeks of Transcranial Magnetic Stimulation (TMS), compared to the control group, with statistically significant difference (p<0.05)

—

Secondary

Measure	Time frame
Expected outcome: reduction in anxiety symptoms, assessed by the Hamilton Anxiety Rating Scale (HAM-A) ;Found outcome: an average reduction of 28% was observed in HAM-A scores in the TMS group, with statistical significance (p<0.05) compared to the control group	—

Countries

Brazil

Contacts

Public ContactRoberto Rodrigues

Santa Casa de Misericórdia de Belo Horizonte

roberto.rodrigues@yahoo.com.br+55 98 8204-4142

Outcome results

None listed

Source: REBEC (via WHO ICTRP)