Osteoradionecrosis
Conditions
Interventions
Test group: 16 subjects previously submitted to radiotherapy for head and neck cancer will receive leukocyte- and platelet-rich fibrin to fill and cover postextraction sockets. Control group: 16 subje
Other
Sponsors
Universidade Ibirapuera
Hospital Heliópolis
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Previous 3D conformational radiotherapy for head and neck cancer; total radiotherapy dose from 50Gy to 70Gy; at least 18 years of age; able to undergo dental surgery.
Exclusion criteria
Exclusion criteria: Disease recurrence (cancer); drugs that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; diseases that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; tobacco use; radiotherapy for head and neck cancer more than once.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the potential effect of Leukocyte- and platelet-rich fibrin on preventing the development of tooth extraction related-osteoradionecrosis sites in patients previously submitted to head and neck cancer radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the potential effect of Leukocyte- and platelet-rich fibrin on reducing pain (assessed via visual analogue scale) and other complications of tooth extraction (clinical features) in patients previously submitted to radiotherapy for head and neck cancer | — |
Countries
Brazil
Contacts
Public ContactLuiz Palma
Universidade Ibirapuera
Outcome results
None listed