Effect of a propolis tablet on the saliva and the amount of adolescent dental plaque microbes comparing with the use of another tablet without propolis

Effect of a propolis-containing tablet on the acidity of saliva and the amount of adolescent dental plaque microbes: a randomized clinical study comparing with the use of another tablet without propolis, and without knowing who will ingest and supply the tablet

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

REBEC

Registry ID

RBR-8xm896

Enrollment

Unknown

Registered

2017-11-22

Start date

2017-09-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries

Interventions

Test tablets (with xylitol and propolis) and control (xylitol only) will be offered in an exact number of days of use to be consumed orally. Collection of total non-stimulated saliva and dental biofil

Eligibility

Age

10 Years to 19 Years

Inclusion criteria

Inclusion criteria: Individuals aged 10-19 years; both genders; individuals without cavitary caries lesions; healthy individuals without any systemic diseases.

Exclusion criteria

Exclusion criteria: Individuals intolerant to some component of the propolis-containing tablet; subjects undergoing antimicrobial treatment during the course of the study or for a period of 30 days prior to the study; individuals who used products containing xylitol up to 30 days before the start of study or during the course of the study; individuals who used products containing propolis up to 30 days before the start of the study or during the course of the study; individuals with orthodontic appliances; individuals who are using oral mouthwashes during the period of study; individuals with a history of intraoral surgery within the last 6 months; individuals who are making use of products rich in polyphenols: coffee, mate, acai, in the previous period (30 days) and during the research; individuals who consume alcohol.

Design outcomes

Primary

Measure	Time frame
Effect of xylitol tablets with and without propolis on the total microorganism count of adolescents biofilm using the scattering technique, considering the number of CFU/mg of biofilm.;Effect of xylitol tablets with and without propolis on the total microorganism count of adolescents saliva using the scattering technique.	—

Secondary

Measure	Time frame
Effect of xylitol tablets with and without propolis on the concentration of soluble and insoluble extracellular polysaccharides of the biofilm of adolescents by means of the phenol-sulfuric method, based on the quantitative carbohydrate.;Acceptability of tablets for the appearance, flavor, aroma and texture of the tablets, by adolescents, by means of a questionnaire with a scale of 9 points.	—

Countries

Brazil

Contacts

Public ContactAndréa Gonçalves

Universidade Federal do Rio de Janeiro

andreagantonio@yahoo.com.br+55(21) 3938 2009

Outcome results

None listed

Source: REBEC (via WHO ICTRP)