Use of lasers for the treatment of hypersensitivity in children with Molar Incisor Hypomineralization (MIH) and the impact on quality of life in relation to oral health

Use of high and low power lasers for the treatment of dentin hypersensitivity in children with Molar Incisor Hypomineralization (MIH) and the impact on quality of life in relation to oral health - MIH Molar Incisor Hypomineralization

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-8xkp7wr

Enrollment

Registered

2024-05-03

Start date

2024-03-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Molar Hypomineralization Stained teeth

Interventions

This is a two-arm randomized clinical trial with a planned sample of 64 teeth, allocated to two intervention groups comprising 32 teeth each. Randomization will be performed at the participant level u

Eligibility

Age

7 Years to 17 Years

Inclusion criteria

Inclusion criteria: Minimum age of 7 years and maximum age of 17 years; presence of molar-Incisor hypomineralization and mild, moderate or severe dentin hypersensitivity in at least 1 tooth with hypomineralization; the guardian must sign the informed consent form (TCLE) and the child, the informed consent form (TALE)

Exclusion criteria

Exclusion criteria: Presence of any type of systemic pathology; presence of pre-malignant lesion; children who do not allow the procedure; partially erupted hypomineralized teeth; hypomineralized teeth with lesions with pulp involvement; hypomineralized teeth with restorations or carious lesions; hypomineralized teeth with orthodontic bands; patients who used desensitizers in the last 3 months

Design outcomes

Primary

Measure	Time frame
Reduction in tooth-level dentine hypersensitivity-related pain intensity. The outcome will be assessed as the difference in pain intensity between baseline and one week after completion of treatment, using the Adapted Pimenta Facial Scale. The difference between the scores obtained at baseline and one week after treatment will be used to determine the reduction in pain intensity;Reduction in tooth-level dentine hypersensitivity-related pain response. The outcome will be assessed as the difference in pain response between baseline and one week after completion of treatment, using the Schiff Cold Air Sensitivity Scale (SCASS), as assessed by the examiner. The difference between the SCASS scores obtained at baseline and one week after treatment will be used to determine the reduction in pain response	—

Measure

Time frame

Reduction in tooth-level dentine hypersensitivity-related pain intensity. The outcome will be assessed as the difference in pain intensity between baseline and one week after completion of treatment, using the Adapted Pimenta Facial Scale. The difference between the scores obtained at baseline and one week after treatment will be used to determine the reduction in pain intensity;Reduction in tooth-level dentine hypersensitivity-related pain response. The outcome will be assessed as the difference in pain response between baseline and one week after completion of treatment, using the Schiff Cold Air Sensitivity Scale (SCASS), as assessed by the examiner. The difference between the SCASS scores obtained at baseline and one week after treatment will be used to determine the reduction in pain response

—

Secondary

Measure	Time frame
Durability of the treatment effect on tooth-level dentine hypersensitivity. The outcome will be assessed at 1 month, 6 months, 1 year, and 2 years after completion of treatment using the Adapted Pimenta Facial Scale and the Schiff Cold Air Sensitivity Scale (SCASS). The maintenance of the reduction in pain intensity and pain response will be evaluated by comparing the scores obtained at each follow-up assessment with the baseline scores;Treatment acceptability. The outcome will be assessed using the Modified Wong-Baker Scale before and immediately after completion of treatment. The change in acceptability scores between the two assessment time points will be used to evaluate treatment acceptability;Impact of treatment on oral health-related quality of life. The outcome will be assessed using the Molar-Incisor Hypomineralization Impact Scale (MIHIS) before treatment and after completion of treatment. The change in MIHIS scores between the two assessment time points will be used to evaluate the impact of treatment on oral health-related quality of life	—

Measure

Time frame

Durability of the treatment effect on tooth-level dentine hypersensitivity. The outcome will be assessed at 1 month, 6 months, 1 year, and 2 years after completion of treatment using the Adapted Pimenta Facial Scale and the Schiff Cold Air Sensitivity Scale (SCASS). The maintenance of the reduction in pain intensity and pain response will be evaluated by comparing the scores obtained at each follow-up assessment with the baseline scores;Treatment acceptability. The outcome will be assessed using the Modified Wong-Baker Scale before and immediately after completion of treatment. The change in acceptability scores between the two assessment time points will be used to evaluate treatment acceptability;Impact of treatment on oral health-related quality of life. The outcome will be assessed using the Molar-Incisor Hypomineralization Impact Scale (MIHIS) before treatment and after completion of treatment. The change in MIHIS scores between the two assessment time points will be used to evaluate the impact of treatment on oral health-related quality of life

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Countries

Contacts

Public ContactGiovanna Marinho

Faculdade de Odontologia da Universidade de São Paulo

giovannamarinho@usp.br+55 11 982077089

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Sep 19, 2026