Nephropaty
Conditions
Interventions
A single-blind, crossover clinical trial was conducted to compare the use of placebo or sertraline in reducing hypotension in patients undergoing hemodialysis. After two patients were excluded from th
Drug
Sponsors
Universidade do Sul de Santa Catarina
Universidade do Sul de Santa Catarina
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 18 years of age or over; both sexes; with kidney failure; who undergo hemodialysis three times a week, with a duration of each session of at least three hours. Patients eligible for the study should present intradialytic hypotension defined by the above criteria in at least 50% of the hemodialysis sessions of the last three months prior to the start of sertraline use
Exclusion criteria
Exclusion criteria: Patients with psychiatric disease or major cognitive deficits; history of drug abuse; patient refusal; refusal of the patient's physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pre and post-dialytic dry weight, need, number and type of interventions performed during HID episode were evaluated. During the hemodialysis session, blood pressure was measured on at least three occasions to calculate mean arterial pressure. A 20% fold reduction was waited in incidence of intradialitic hypotension | — |
Secondary
| Measure | Time frame |
|---|---|
| The laboratory tests were evaluated according to routine collection by the Hemodialysis Clinic. Seric levels of calcium, bicarbonate, sodium, potassium and magnesium was measured and corrected if necessary. There were not differences in electrolytes correction needed between the groups | — |
Countries
Brazil
Contacts
Public ContactChristine Dalmolin
Universidade do Sul de Santa Catarina
Outcome results
None listed