Renal Insufficiency
Conditions
Interventions
All volunteers will be submitted to an initial evaluation, followed by ambulatory monitoring of arterial pressure (ABPM), laboratory tests, pulse wave velocity (VOP), echocardiogram, exercise test, qu
Other
E02.760.169.063.500.387
Sponsors
Faculdade de Medicina de Botucatu
Faculdade de Medicina de Botucatu
Eligibility
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age greater than or equal to 18 years; both sexes; with CKD in hemodialytic treatment for a period of more than or equal to 3 months; plasma Aldo above 15 ng / dL; do not present contraindications for performing physical activity.
Exclusion criteria
Exclusion criteria: Patients with cognitive deficits, diagnosis of psychiatric disorders; amputees; pregnant women and non-literates; with a previous diagnosis of coronary artery disease; patients considered to be active or very active according to the IPAQ questionnaire, chronic uncontrolled arterial hypertension with BP of 160/100 mm Hg, positive exercise test for cardiac ischemia; patients who suffered a stroke and / or acute myocardial infarction, neoplasia patients; hepatic insufficiency and patients receiving; spironolactone, occurrence of active infection; change in class and / or drug dose; use of antihypertensives; including use of spironolactone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To decrease the serum concentration of Aldosterone, the methodology of collection, processing and storage will be guided by this laboratory and the method used to analyze the plasma aldosterone activity will be the enzyme immunoassay, based on a 25% variation in pre and post measurements -intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 8% reduction in the left ventricular mass, evaluated by Echocardiogram, 10% decrease in the pulse wave velocity evaluated by the SphygmoCor CPV apparatus and a 10% increase in the physical wellness domains, evaluated by the instrument Kidney Disease and Quality of Life Short -Form and 10% increase in functional capacity assessed by the ergometric test. | — |
Countries
Brazil
Contacts
Public ContactBruna Pianna
Universidade do Sagrado Coração
Outcome results
None listed