Comparison of Two Types of General Anesthesia, Venous versus Inhalatory, regarding the Risk of Renal Injury after Videolaparoscopic Obesity Surgery

Efficacy of Total Intravenous Anesthesia (TIVA) in blocking Perioperative Elevation of NGAL in Laparoscopic Bariatric Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

REBEC

Registry ID

RBR-8wt2fy

Enrollment

Unknown

Registered

2014-08-13

Start date

2010-10-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute renal failure, morbid obesity

Interventions

Sixty-four morbidly obese patients undergoing elective laparoscopic obesity surgery were randomly selected for total intravenous anesthesia ( TIVA ) or inhalation anesthesia ( SEVO ), 32 patients eac

M1 - 6 hours after surgery and M2 - 24 hours after surgery.

Drug

Procedure/surgery

E03.155.197.197

E03.155.308

E02.065.062

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: morbidly obese patients, scheduled for video laparoscopic bariatric surgery; both gender; age between 18 and 65 year.

Exclusion criteria

Exclusion criteria: volunteers with lung disease; heart failure; renal failure; cancer of any etiology; patients on chronic corticosteroid use; that are not available to participate in all stages of the study.

Design outcomes

Primary

Measure	Time frame
Expected primary outcome - Difference of 33% on average values of serum lipocalin 2 (NGAL) during the perioperative period of video laparoscopic bariatric surgery between the two groups of general anesthesia;Observed primaryoutcome - We did not find significant differences in serum lipocalin between the groups for general anesthesia during the procedure	—

Secondary

Measure	Time frame
Expected secondary outcomes - Change in the rate of acute renal injury, evidenced by clinical and laboratory markers (urine output and serum creatinine, translated into RIFLE criteria) in the perioperative period of laparoscopic bariatric surgery according to the type of anesthesia used;Secondary outcomes observed - We did not find significant differences in the rates of acute kidney injury defined by clinical and laboratory criteria (RIFLE criteria) between the two groups of general anesthesia in the perioperative period of laparoscopic bariatric surgery	—

Measure

Time frame

Expected secondary outcomes - Change in the rate of acute renal injury, evidenced by clinical and laboratory markers (urine output and serum creatinine, translated into RIFLE criteria) in the perioperative period of laparoscopic bariatric surgery according to the type of anesthesia used;Secondary outcomes observed - We did not find significant differences in the rates of acute kidney injury defined by clinical and laboratory criteria (RIFLE criteria) between the two groups of general anesthesia in the perioperative period of laparoscopic bariatric surgery

—

Countries

Brazil

Contacts

Public ContactAdriano;Norma Sueli Fernandes;Módolo

faculdade de medicina de Botucatu-UNESP;faculdade de medicina de Botucatu-UNESP

atfernandes@yahoo.com.br;nmodolo@fmb.unesp.br+55(14)38116022;+55(14)38116022

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Mar 18, 2026