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Effect of the association of Dexamethasone with Ibuprofen on Anesthetic Success, Postoperative Pain and Quality of Life after Root Canal Treatment in patients with Preoperative Pain

Effect of Supraperiosteal Injection of Dexamethasone associated with Ibuprofen on Anesthetic Success, Postoperative Pain and Quality of Life after Endodontic Treatment in patients with Irreversible Pulpitis

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
REBEC
Registry ID
RBR-8wc3mj5
Enrollment
Unknown
Registered
2024-09-17
Start date
2023-08-21
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulpitis

Interventions

This is a double-blind, placebo-controlled clinical trial. A total of sixty volunteers with mild to severe preoperative pain will be randomly divided into three groups (n=20 per group): DI – dexamenta

Sponsors

Fundação Francisco Mascarenhas/Faculdade Integradas de Patos-FIP
Lead Sponsor
Universidade Federal de Campina Grande
Collaborator

Eligibility

Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Systemically healthy patients of any gender aged between 18 and 65 years; teeth diagnosed with symptomatic or asymptomatic irreversible pulpitis and symptomatic apical periodontitis (presence of preoperative pain); and preoperative pain ranging from mild to severe on the Heft Parker visual analogue scale

Exclusion criteria

Exclusion criteria: Pregnant or breastfeeding women; patients with allergies, sensitivity or adverse reactions to dexamethasone or ibuprofen; individuals who received any analgesic or anti-inflammatory in the last 12 hours before treatment; and non-restorable teeth, with periodontal disease, root resorption, open apex and calcified root canals

Design outcomes

Primary

MeasureTime frame
It is expected to reduce postoperative endodontic pain within 7 days with the combined use of ibuprofen and dexamethasone

Secondary

MeasureTime frame
It is expected to see an increase in the anesthetic success rate and improvement in postoperative quality of life within 7 days with the combined use of ibuprofen and dexamethasone

Countries

Brazil

Contacts

Public ContactFelipe Matos

Universidade Federal de Campina Grande

felipe.souza@professor.ufcg.edu.br+55 (79) 999756002

Outcome results

None listed

Source: REBEC (via WHO ICTRP)