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Effect of Anti Microbial Photodynamic Therapy on the Treatment of Oral Candidosis

Use of Anti-Microbial Photodynamic Therapy in the treatment of Oral Candidose: Clinical, controlled and randomized test

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
REBEC
Registry ID
RBR-8w8599
Enrollment
Unknown
Registered
2019-12-09
Start date
2019-05-08
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Candidiasis, Oral

Interventions

Intervention group: 15 patients with candidiasis erythematosus will receive photodynamic therapy using methylene blue on the oral candidiasis lesion and prosthesis once a week for approximately 21 day
Drug
Radiation
E02.186.500

Sponsors

Universidade Federal do Rio Grande do Norte
Lead Sponsor
Universidade Federal do Rio Grande do Norte
Collaborator

Eligibility

Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Cases of patients with erythematous candidiasis located in the oral mucosa; Patients older than 18 years and under 100 years old; Patients who do not receive treatment for other diseases with systemic antifungal

Exclusion criteria

Exclusion criteria: Patients with other types of oral candidiasis; Pregnant women; Patients who did not receive nystatin treatment at least six months prior to the start of the study; Patients who do not attend for follow-up;Patients older than 100 years

Design outcomes

Primary

MeasureTime frame
To evaluate the remission of oral candidiasis lesions after treatment with aPDT at or less than nystatin-treated patients over time in weeks.

Secondary

MeasureTime frame
Verify PDT is a more efficient treatment modality for the elimination of fungal species colonies, check by counting CFUs.

Countries

Brazil

Contacts

Public ContactÉricka ;Maurília Silveira;Medeiros

Universidade Federal do Rio Grande do Norte;Universidade Federal do Rio Grande do Norte

ericka_janine@yahoo.com.br;mauriliaraquel@hotmail.com+55-084-3215-4138;+55-084-99641-3557

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 10, 2026