Dental fluorosis
Conditions
Interventions
Participants will be submitted to four treatment groups: group I- Fresh dentifrice with 1332.5 ppm of fluoride (F), group II to IV: aged dentifrice having 1113.5, 796.6 and 667.4 ppm of F, respectivel
Other
Sponsors
Faculdade de Odontologia de Piracicaba
Faculdade de Odontologia de Piracicaba
Eligibility
Inclusion criteria
Inclusion criteria: participants in good general health; participants with normal salivary flow (unstimulated saliva equal to or greater than 0.3 to 0.4 mL per min)
Exclusion criteria
Exclusion criteria: participants with kidney disease; participants with gastrointestinal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The concentration of fluoride in the blood plasma is expected to be proportional to the amount of total soluble fluoride ingested. The fluoride concentration in the plasma will be analyzed with the aid of the specific ion electrode, and the calculation of the area under the curve will be performed. Blood samples will be collected at 0 min (before ingestion) and for 180 min after ingestion.;The concentration of fluoride in saliva is expected to be proportional to the amount of total soluble fluoride ingested. The concentration of fluoride in the saliva will be analyzed with the aid of the specific ion electrode, and the calculation of the area under the curve will be performed. Saliva samples will be collected at 0 min (before ingestion) and for 180 min after ingestion.;The amount of F excreted in the urine is expected to be proportional to the amount of total soluble fluoride ingested. Urine samples will be collected 24 hours before ingesting the suspension and 24 hours afterwards. The concentration of F in the urine will be assessed with a specific fluoride ion electrode. The value of the fluoride concentration in the urine found will be multiplied by the total volume collected to determine the amount of fluoride excreted. | — |
Secondary
| Measure | Time frame |
|---|---|
| Are not expected secondary outcomes | — |
Countries
Brazil
Contacts
Public ContactDeborah da Rocha
Faculdade de Odontologia de Piracicaba
Outcome results
None listed