Bacterial infections and mycoses
Conditions
Interventions
This is a two-arm, double-blind, randomized controlled clinical trial. Procedure: periodontal treatment through mechanical debridement, with scaling and subgingival smoothing. This procedure will be p
G07.203.300.456.500
Sponsors
Universidade Estadual Paulista Júlio de Mesquita Filho
Universidade Estadual Paulista Júlio de Mesquita Filho
Eligibility
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: Individuals over 35 years old; patients with type 2 diabetes mellitus; carriers of generalized chronic periodontitis; present at least 16 teeth; agree to participate in the study and sign the informed consent form for participation in the research
Exclusion criteria
Exclusion criteria: Patients with cardiovascular disease, cancer, gastrointestinal disorders, skin diseases, pregnancy, lactation, smoking, arthritis, lupus; have undergone periodontal treatment in the last 12 months; have made use of antioxidant, anti-inflammatory, or antibiotic supplements within the previous 3 months; have changed the blood glucose control medication in the last 3 months; present dental elements with pulp or periapical inflammation; have any other diseases of inflammatory origin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: It was expected to find a greater reduction in the pocket depth measured, the primary variable of the study, in the group with adjuvant therapy with the probiotic, verified through clinical periodontal examination. It was also expected to assess the response of inflammatory mediators and the lipid and microbiological profile to the applied intervention.;Outcome found 1: Through the clinical examination, there was a reduction in probing depth in both groups, a reduction in the amount of periodontopathogenic bacteria in periodontal pockets and a change in the lipid profile of the probiotic group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes were not expected. | — |
Countries
Brazil
Contacts
Public ContactMaria Aparecida Jardini
Universidade Estadual Paulista Júlio de Mesquita Filho
Outcome results
None listed