Kidney disease
Conditions
Interventions
The physical exercise groups – Partial blood flow restriction training group (GRFS) and exercise without partial blood flow restriction group (GE) - undergo an exercise protocol composed of 20 minutes
Mesocycle 2 - Weeks 5 - 8: participants will pedal to a HR between 64% and 76% of the maximum HR, corresponding to 12-13 on the perceived exertion scale of 6 to 20 (BORG, 1982).
An exercise session fo
2) with the patient standing, fitting the blood flow restriction accessory
3) with the patient sitting in the hemodialisy’s chair, pressurized band inflation for RFS
4) positioning of the ergometric bicycle in front of the patient
and 5) pedaling.
The maximum HR determined from the following formula (NES et al., 2013):
HRmax = 211 - (0.64x age).
Patients who use HR-influencing medication, such as beta-blockers, will have their
Behavioural
G11.427.590.530.698.277
Sponsors
Escola Superior de Educação Física/Universidade Federal de Pelotas
Universidade Católica de Pelotas
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patients with chronic kidney disease on hemodialysis; 18 years of age or over; both sexes.
Exclusion criteria
Exclusion criteria: With previous diagnosis of coronary artery disease; submitted to mechanical ventilation and hospitalized in the intensive care unit; with musculoskeletal limitation that impedes the performance of the exercise; with cognitive alterations that make it impossible to understand the instructions of the exercises; pregnant women; individuals with a history of deep venous thrombosis; with systolic blood pressure greater than or equal to 180 mmHg or greater diastolic equal to 105 mmHg at rest and resting heart rate greater than or equal to 120 bpm at rest; practitioners of any physical exercise program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory markers: interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF), assessed by the ELISA method, at baseline (week 0) and at the end (week 12) of the study. It is expected to reduce levels of IL-6 and TNF and increase in IL-10 concentration among patients in the exercise groups exercise.;Oxidative stress markers: superoxide dismutase, glutathione peroxidase and catalase activity, assessed by enzymatic methods, at the beginning (week 0) and at the end (week 12) of the study. The levels of these enzymes are expected to increase among patients in the exercise groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional ability, assessed by the six-minute walk test at the beginning (week 0) and at the end (week 12) of the study. The distance traveled between patients belonging to the exercise groups is expected to increase.;Muscle strength, assessed by thoraco-lumbar dynamometry, at the beginning (week 0) and at the end (week 12) of the study. An increase in strength levels is expected among patients in the exercise groups.;Muscle thickness, assessed by ultrasound, at the beginning (week 0) and at the end (week 12) of the study. An increase in muscle thickness is expected among patients in the exercise groups.;Quality of life, assessed by the Kidney Disease Quality of Life Short Form - version 1.3 (KDQOL-SF) scores at the beginning (week 0) and at the end (week 12) of the study. It is expected to improve the quality of life of the patients belonging to the exercise groups. | — |
Countries
Brazil
Contacts
Public ContactRodrigo Cardoso
Escola Superior de Educação Física/Universidade Federal de Pelotas
Outcome results
None listed