Pain reduction compared postoperative period with the use of morphine versus methadone during anesthesia in cardiac surgery.

Postoperative analgesia comparing the Methadone versus Morphine during anesthetic induction in cardiac surgery

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

REBEC

Registry ID

RBR-8spkx9

Enrollment

Unknown

Registered

2015-10-13

Start date

2015-08-02

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracic Surgery

Interventions

All study participants (intervention group and control group will undergo the same anesthetic procedure described below: anesthesia induction is performed with sufentanil 0.5 micrograms per kilogram o

ie 40 patients who will receive a methadone dose (treatment group - intervention) at the end of surgery and 40 who will receive equivalent dose of morphine (control group - no treatment).The doses of

Drug

D02.522.675

D03.132.577.249.562.571

Eligibility

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Volunteers undergoing cardiac surgery myocardial revascularization without cardiopulmonary bypass; Both genders; ASA (American Society of Anesthesiologist) III or IV;

Exclusion criteria

Exclusion criteria: Volunteers with a history of illicit drug use; allergy to morphine or methadone; post-operative intubation than 48 hours.

Design outcomes

Primary

Measure	Time frame
Postoperative analgesia measured by the scale of pain and analgesic rescue doses. The pain will be measured by visual analogue scale 12, 24 and 36 hours after surgery.	—

Secondary

Measure	Time frame
Adverse effects of anesthetic and analgesic used.	—

Countries

Brazil

Contacts

Public ContactFabiana Schuelter-Trevisol

Universidade do Sul de Santa Catarina

fastrevisol@gmail.com+55 (48)36317239

Outcome results

None listed

Source: REBEC (via WHO ICTRP)