Chronic Obstructive Pulmonary Disease, Unspecified / Chronic Obstructive Pulmonary Disease
Conditions
Interventions
The study contains two work packages: 1) cross-over study and 2) randomized controlled trial.
Cross-over study design:
Fifteen individuals will be randomly assigned to three series of supplementation:
(2) beetroot supplementation and (3) placebo appearance similar to L-arginine. Each series will last 14 days, and a seven day washout period will be done between each series. Patients will initially u
(2) L-arginine supplementation group and (3) beetroot supplementation group. Each group will have 15 patients, totaling 45 participants in the randomized clinical trial.
Patients will participate in t
localized muscle training of lower limbs (major muscle groups related to walking, 2 to 3 sets of 6 to 12 repetitions with work load between 50-85% of 1RM) and upper limbs (high number of repetitions,
Dietary supplement
Other
E02.760.169.063.500.387
SP6.051.227
Sponsors
Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA
Irmandade Santa Casa de Misericórdia de Porto Alegre
Eligibility
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with moderate to very severe chronic obstructive pulmonary disease; with age equal to or greater than 40 years; of both sexes.
Exclusion criteria
Exclusion criteria: Current smoking; presence of associated diseases that make it impossible to carry out any of the study evaluations or limit the progression of training such as osteoarthritis, severe cardiovascular and neurological conditions and non-signing of the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in endothelial function assessed by brachial artery flow-mediated dilation by means of brachial artery ultrasound performed at the beginning and end of each cross-over series of supplementation and before and after 24 sessions of pulmonary rehabilitation.;Change in endothelial function assessed by the index of reactive hyperemia by means of peripheral arterial tonometry performed at the beginning and at the end of each cross-over series of supplementation and before and after 24 sessions of pulmonary rehabilitation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of functional capacity determined by a minimum increase of 25 meters in the distance covered in the six-minute walk test performed before and after 24 sessions of pulmonary rehabilitation.;Improvement in exercise capacity determined by an increase in maximal oxygen uptake during cardiopulmonary exercise testing performed before and after 24 sessions of pulmonary rehabilitation.;Changes in plasma levels of nitrites and nitrates assessed at the beginning and at the end of each series of cross-over series of supplementation and before and after 24 sessions of pulmonary rehabilitation.;Change in body composition by quantifying mass of adipose mass, muscle mass, bone mass, body mass and skin mass using the International Society for the Advancement of Kinanthropometry (ISAK) method before and after 24 sessions of pulmonary rehabilitation.;Change in the daily physical activity level evaluated by the number of steps and intensity of walking, by means of a triaxial accelerometer, before and after 24 sessions of pulmonary rehabilitation. | — |
Countries
Brazil
Contacts
Public ContactPedro Dal Lago
Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA
Outcome results
None listed