Multiple Sclerosis.
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients with clinical diagnosis of Multiple Sclerosis in remitting-recurrent form according to the revised McDonald criteria; EDSS (Expanded Disability Status Scale) up to 6.0 according to the Kurtzke scale; Stable phase of the disease (after any 30 days of the outbreak); Orbicular strenght of the lips sufficient to support the mouthpiece during respiratory assessment.
Exclusion criteria
Exclusion criteria: Any neurological disorder other than Multiple Sclerosis; History of primary cardiopulmonary diseases; Difficulty to understand simple instructions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue: will be assessed using the Fatigue Severity Scale, which consists of a numerical scale composed of 9 questions with scores ranging from 1 to 7 each, where 1 represents strong disagreement and 7 maximum agreement. Values above 28 points can be considered as indicators of the presence of fatigue. The Chalder Fatigue Scale will also be used, which contains 11 items with scores from 0 to 3 each, where the values 0 and 1 are considered as zero and the values 2 and 3 as one. The sum of the values greater than or equal to 4 characterizes the presence of fatigue. Fatigue will be evaluated before and after the intervention. ;Strength: will be assessed by means of manovacuometry, which consists of measuring MIP and MEP at the level of functional lung capacity and residual volume. Indexes less than - 70 cmH2o of MIP and less than 95 cmH2o of MEP characterize the degree of weakness. Strength will be evaluated before and after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic respiratory function: it will be evaluated by means of spirometry, where the variables analyzed will be the forced vital capacity, the forced expiratory volume and the peak expiratory flow. Respiratory function will be assessed before and after the intervention.;International Classification of Functionality and Disability: will be used to describe the muscular fatigue of the evaluated patients. | — |
Countries
Brazil
Contacts
Faculdade de Medicina da Universidade Federal de Goiás