Sarcopenia
Conditions
Interventions
his is a randomized, controlled, double-blind clinical trial with allocation concealment. The sample will consist of 28 participants with pre-dialytic chronic kidney disease stages III and IV, randoml
Sponsors
Departamento de Fisioterapia
Departamento de Fisioterapia
Eligibility
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with pre-dialysis stage chronic kidney disease, confirmed by clinical or laboratory criteria as prescribed by the National Kidney Foundation, will be included; of both sexes; aged between 30 and 70 years; clinically stable and without recent exacerbations; with the ability to understand and participate in the proposed assessment and exercise program
Exclusion criteria
Exclusion criteria: Patients undergoing renal replacement therapy such as hemodialysis, peritoneal dialysis, or kidney transplantation; those with acute or chronic respiratory diseases; those with neurological and/or musculoskeletal conditions that interfere with performing respiratory exercises; those with cognitive or behavioral impairments that prevent participation in the study or compliance with protocol instructions; and those with any other medical condition that makes them ineligible to participate in the study will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate peripheral muscle strength of the upper and lower limbs, expecting an increase in strength after the resistance training protocol, verified by means of dynamometry for handgrip strength assessment and by the one-repetition maximum test for the main muscle groups trained during the intervention.;To evaluate maximal inspiratory muscle strength, expecting an increase in maximal inspiratory pressure values after the intervention, verified by means of manovacuometry with measurement of Maximal Inspiratory Pressure using properly calibrated equipment.;To evaluate pulmonary function, expecting improvement in spirometric parameters after the training period, verified by means of spirometry with measurement of Forced Vital Capacity, Forced Expiratory Volume in the first second, Peak Expiratory Flow, and the ratio between Forced Expiratory Volume in the first second and Forced Vital Capacity according to current technical guidelines.;To evaluate participants’ functional mobility, expecting a reduction in test execution time after the intervention, verified by means of the Timed Up and Go method with time measurement in seconds to stand up from a chair, walk three meters, return, and sit down again. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the classification of sarcopenia among participants, expecting a reduction in the prevalence of risk or diagnosis of sarcopenia after the training protocol, verified by means of the SARC-F questionnaire associated with the cut-off points established by the European Working Group on Sarcopenia in Older People for the diagnosis of sarcopenia. ;To evaluate calf circumference as an indirect marker of peripheral muscle mass, expecting to identify an increase in this measurement after the intervention period, verified by means of anthropometric assessment using a non-elastic measuring tape positioned at the point of greatest calf circumference.;To evaluate participants’ body composition, expecting to observe improvements in parameters related to muscle mass and a possible reduction in alterations associated with sarcopenia after the intervention, verified by means of bioelectrical impedance analysis using a validated device to estimate lean mass, fat mass, and muscle mass index.;To evaluate the thickness of the quadriceps femoris muscle and the diaphragm, expecting to observe an increase in these measurements after the intervention period, verified by means of musculoskeletal ultrasonography using a standardized protocol for muscle thickness assessment at rest. | — |
Countries
Brazil
Contacts
Public ContactBeatriz Marinho Cunha
Programa de Pós-graduação em Fisioterapia - Universidade Federal de Pernambuco
Outcome results
None listed