Heart Failure
Conditions
Interventions
Study with intervention type physical training in individuals with heart failure (HF) with preserved HFPEF)or reduced ejection fraction (HFREF. During randomization, individuals will be allocated in t
Device
Other
E02.760.169.063.500.387.875
G11.427.410.698.277
E01.370.225.998.110
Sponsors
Hospital Universitário Maria Rosa Pedrossian
Universidade Federal de Mato Grosso do Sul
Eligibility
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients of both sexes; Age between 35 and 75 years old; Patients with chronic coronary artery disease by clinical and angiographic criteria, in different degrees of diastolic dysfunction by echocardiographic criteria; Patients who are stable for more than 30 days of symptoms, in regular use of prescription drugs; Patients with HFPEF (LVEF higher than 50%) or HFREF (Ejection Fraction between 30% and 50%);Assessed patients should be able to perform transthoracic doppler echocardiography, inspiratory muscle assessment, peripheral vascular doppler, treadmill exercise cardiopulmonary exercise testing, and to respond to the Minnesota quality of life questionnaire voluntarily before and after the experimental intervention
Exclusion criteria
Exclusion criteria: HF patients and EF lower than 30%; HF patients and EF higher than 30% in Functional Class IV; Recent myocardial infarction (less than 30 days), unstable angina (more than 30 days) or sustained complex ventricular arrhythmia; Severe valvulopathies with surgical indication; Uncontrolled SAH: systolic BP higher than 190 mmHg or diastolic BP higher than 120 mmHg; Inability to exercise on a treadmill due to severe neuromuscular, neurological, orthopedic or psychological limitation; Patients without echocardiographic criteria of diastolic dysfunction by either pulsed or tissue Doppler; Patients with nonobstructive coronary insufficiency or nonatherosclerotic coronary heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the Oxygen Uptake Efficiency Slope. We estimate an increase in the primary outcome value greater than the 5% coefficient of variation after 12-weeks training | — |
Secondary
| Measure | Time frame |
|---|---|
| Increased exercise capacity by measuring maximal oxygen uptake greater than 7% in the treatment group compared to the control group;Significant reduction in exercise natriuretic peptide serum neurohormone level in the treatment group compared to the control group ;A statistically significant increase in the variation of the brachial artery caliber after treatment compared to the control group | — |
Countries
Brazil
Contacts
Public ContactEduardo Reigota
Hospital Universitário Maria Rosa Pedrossian
Outcome results
None listed