Knee osteoarthritis,study of the muscle morphology, prevention of neuromuscular disorders in humans with early degrees of knee osteoarthritis, assessment of quality of life, compared with healthy humans.
Conditions
Interventions
Sponsors
Paula Regina Mendes da Silva Serrão
Universidade Federal de São Carlos
Eligibility
Sex/Gender
Male
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: The following inclusion criteria were used: male, sedentary, aged between 40 and 65 years. All the subjects underwent a radiological examination of both knees to confirm that they displayed signs of osteoarthritis (OA) (for osteoarthritis group) or not (for control group), such as the presence of osteophytes in at least one of the compartments of a knee joint (tibiofemoral or patellofemoral). In OA group the severity of OA was graded by a radiologist according the Kellgren & Lawrence system. We included in the OAG only those subjects with Grade I or II OA of the knee. In the control group the subjects should not present history of pain, trauma, surgery or fractures of the lower limbs.
Exclusion criteria
Exclusion criteria: The exclusion criteria were: physical therapy (previous 12 months); knee or hip surgery; history of lower limb trauma; corticosteroid infiltration of the knee (previous 6 months); medical condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To detect that subjects with knee osteoarthritis show morphological muscle and neuromuscular changes that may already be present in early degrees of knee osteoarthritis. To evaluate the outcomes data will be compared torque and acceleration time (obtained during isokinetic evaluation) between healthy subjects and subjects with knee osteoarthritis. It will also analyze the proportion and type of muscle fibers through the morphological analysis of the muscular fragments, which also compared healthy subjects with subjects with knee osteoarthritis | — |
Secondary
| Measure | Time frame |
|---|---|
| Through the results of the primary outcomes will be provided a scientific basis to contribute to the clinical practice, directing rehabilitation programs | — |
Countries
Brazil
Contacts
Public ContactPaula Serrão
Universidade Federal de São Carlos
Outcome results
None listed