Study of andiroba oil in the healing of mucositis

Evaluation of anti-inflammatory, cicatricial and toxicological activities of andiroba oil - carapa guianensis aubl (meliceae) on oral mucosite in patients submitted to quimioterpia

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

REBEC

Registry ID

RBR-8ptbqn

Enrollment

Unknown

Registered

2018-09-17

Start date

2018-05-10

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mucositis

Interventions

Experimental Group 5 Pacientes do Hospital Ophir Loyola que realizam o tratamento quimioterápico e o desenvolvimento mucosite oral, sendo submetidos ao tratamento com óleo de andiroba em orobase, ond

Drug

HP2.018.262

Eligibility

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Have clinical signs of induced oral mucositis; age equal to or greater than 18 years; complete consciousness; with no history of radiotherapy; not receiving systemic antibiotics and antifungal drugs nor mouthwash during the study

Exclusion criteria

Exclusion criteria: Being under 18 years of age, having undergone radiation therapy and taking antifungal drugs

Design outcomes

Primary

Measure	Time frame
healing and reduction of oral mucositis pain . And for the aid in the evaluation of the degree of severity, will have the help of a table recommended by Lima ET.al (2005) 27. This table classifies oral mucositis in 4 scores: ? Score 0: Absent or discrete hyperemia and erythema, absent hemorrhage, absence of ulcers and abscesses. ? Score 1: Moderate hyperemia and erythema, absent hemorrhage, absence of ulcers and abscesses, presence of scar tissue. ? Score 2: Severe hyperemia and erythema, presence of hemorrhage and small ulcers (up to 1cm in diameter), presence of larger tissue area scarring and absence of abscesses. ? Score 3: Severe hyperemia and erythema, presence of hemorrhage, extensive ulcers and abscesses. It is expected that the degree of murosite	—

Measure

Time frame

healing and reduction of oral mucositis pain . And for the aid in the evaluation of the degree of severity, will have the help of a table recommended by Lima ET.al (2005) 27. This table classifies oral mucositis in 4 scores: ? Score 0: Absent or discrete hyperemia and erythema, absent hemorrhage, absence of ulcers and abscesses. ? Score 1: Moderate hyperemia and erythema, absent hemorrhage, absence of ulcers and abscesses, presence of scar tissue. ? Score 2: Severe hyperemia and erythema, presence of hemorrhage and small ulcers (up to 1cm in diameter), presence of larger tissue area scarring and absence of abscesses. ? Score 3: Severe hyperemia and erythema, presence of hemorrhage, extensive ulcers and abscesses. It is expected that the degree of murosite

—

Secondary

Measure	Time frame
Decreased pain: The analogue visual scale based on a straight line of 100mm will be used, with 0mm the absence of pain and 100mm the greatest pain possible (adapted from MITCH & HELLYER, 2002).	—

Countries

Brazil

Contacts

Public ContactGEORGE;George CARACAS;CARACAS

Universidade Federal do Pará;Universidade Federal do Pará

george.cararas@gmail.com;george.cararas@gmail.com055 91 992498255;+55-091992498255

Outcome results

None listed

Source: REBEC (via WHO ICTRP)