Body weight
Conditions
Interventions
Fourthy four women and forthy one men, eutrophic and overweight will daily intake 500 mL of orange juice during 60 days.
At the first day, after 12h fasting, body composition will be evaluated, and bl
G07.203.300.456
Sponsors
Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
Hospital Universitário da Universidade de São Paulo
Eligibility
Age
19 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy individuals; aged 19 to 40 years; with nutritional diagnosis of eutrophy and / or overweight (BMI = 19.0-24.99 Kg / m2 and 25 to 29.9 Kg / m2). Do not have a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; not be an alcoholic (daily alcohol consumption); not be diabetic; not have any type of infection; not using vitamin and mineral supplements, in addition to antibiotics, antacids or medication for diarrhea or constipation; not be a smoker; not having an aversion to orange juice; women volunteer cannot be pregnant, breastfeeding or undergoing hormone replacement therapy for menopause.
Exclusion criteria
Exclusion criteria: Present a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; being an alcoholic (daily alcohol consumption); being diabetic; presenting any type of infection; be using vitamin and mineral supplements, in addition to antibiotics, antacids or medications for diarrhea or constipation; being a smoker; aversion to orange juice; pregnant women, lactating women or menopausal hormone replacement therapy.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| A decrease in some pro-inflammatory cytokines were expected after orange juice consumption, analysed by flow cytometry. It was possible to observed a significant reduction (p lower than 0.05) of some pro-inflammatory cytokines, IL-2, IL-6, ICAM-1, VCAM-1. Cytokines evaluated: Interleukines (IL) IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, interferon-? (IFN-?), tumor necrosis factor (TNF-a), C-reactive protein (PCR), adiponectin, monocyte chemoattractant protein-1 (MCP-1), Intercelulatr adhesion molecule-1 (ICAM-1) and vascular cell adhesion-1 (VCAM-1) | — |
Primary
| Measure | Time frame |
|---|---|
| An improvement on biochemical blood parameters was expected after orange juice consumption, analysed by classical biochemical analysis. The individuals responded differently to the consumption of orange juice. After 60 days of ingestion of orange juice, a reduction in the percentage of body fat was observed, and through biochemical tests, a reduction in liver enzymes glutamic oxalacetic transaminase (TGO) and glutamic piruvic transaminase (TGP) and triglycerides was observed. Evaluated parameters: glycemy, insulin, total cholesterol, high density lipoprotein, low density lipoprotein, TGO, TGP, blood pressure, body weight, body fat percentage. | — |
Countries
Brazil
Contacts
Public ContactNeuza Hassimotto
Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
Outcome results
None listed