Appetite regulation
Conditions
Interventions
This is a randomized, crossover, controlled-diet, open-label clinical trial with four study arms. A total of 44 participants will be included, stratified by nutritional status into 22 obese individual
without obesity). For each stratum, an independent allocation list will be generated in blocks of four individuals. The numbers in this sequence will correspond to the four possible sequences derived
Sponsors
Faculdade de Nutrição da Universidade Federal de Alagoas
Laboratório de Nutrição e Metabolismo da Universidade Federal de Alagoas
Eligibility
Age
19 Years to 30 Years
Inclusion criteria
Inclusion criteria: Ages 19 to 30; both sexes; with a body mass index between 18.5 and 24.9 kg/m²; body fat percentage determined by electrical bioimpedance of less than 25% for men and less than 35% for women for individuals without obesity; and a body mass index above 30 kg/m²; body fat percentage greater than or equal to 25% for men and greater than or equal to 35% for women for individuals with obesity; weight stable for at least 1 month
Exclusion criteria
Exclusion criteria: Smokers; heavy drinkers; women who are pregnant, breastfeeding, or in menopause; chronic use of any medications that affect appetite and/or energy intake, such as glucagon like peptide 1 receptor agonists or related drugs, antidepressants, and others; conditions that prevent the performance of anthropometry or measurement of energy expenditure components; food intolerances, allergies, or dietary restrictions regarding the provided meals; indications of an eating disorder, as assessed by the Eating Disorder Examination Questionnaire Short
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ad libitum energy intake at lunch will be assessed using the plate waste method. Energy intake will be observed and expressed in kilocalories | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective measures of appetite are expected to be assessed using the Visual Analog Scale in digital format, applied across 7 dimensions: hunger, fullness, desire to eat, ability to eat, pleasure, and familiarity. Scores ranging from 0 to 100 will be observed, expressed as area under the curve, collected before the standard breakfast following a 12-hour fast and at 30, 60, 90, 120, 180, and 240 minutes after its completion, as well as immediately after finishing the ad libitum lunch for the pleasure and familiarity dimensions;Eating rate is expected to be assessed through real-time monitoring of the consumption of the meal provided, using a camera and a manual counter (WESTERN® - CNE-01, China), conducted by two trained, independent researchers. Grams consumed per minute, milliliters consumed per minute, and calories consumed per minute for both solid and liquid foods, as well as the number of bites/spoonfuls and chews will be observed. These parameters will be calculated from the period between the first bite and the last swallow, using the average between the two researchers, provided the difference between their counts does not exceed 2.5% | — |
Countries
BR
Contacts
Public ContactNassib Bueno
Univerisidade Federal de Alagoas
Outcome results
None listed