Hypertension.
Conditions
Interventions
Groups: normotensives and hypertensives
Normotensives: Evaluated without any teraphy
Hypertensives: different oral therapies, administered for 4 weeks each (random and double blinded). Therapies = cap
Drug
Other
F01.145.632
D27.505.519.389.745.085
Sponsors
Escola de Educação Física e Esporte da Universidade de São Paulo
Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP
Eligibility
Sex/Gender
Male
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Men. Aged between 30 and 60 years. Non smokers. Physically inactives (did not perform physical activity more than twice a week). Normotensives and hypertensives will form different groups. Hypertensives should not have end organ damage or secondary causes of hypertension according to the diagnotic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, USP.
Exclusion criteria
Exclusion criteria: Subjects with obesity (body mass index equal or greater than 30 kg/m2). Subjects with diabetes (fasting glycemia equal or greater than 126 mg/dl). Subjects with cardiac diseases (previous diagnosis or alteration on resting or exercise ECG). Subjects who do not tolerate the study medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| post-exercise hypotension - evaluated by the measurement of clinic (auscultatory) and ambulatorial (oscillometric) blood pressure before and after rest and resistance exercise while receiving placebo and captopril. | — |
Secondary
| Measure | Time frame |
|---|---|
| hemodynamics - evaluated by the measurement of cardiac output (CO2 rebreathing)and heart hate (ECG) performed before and after rest and resistance exercise while receiving placebo and captopril. Systemic vascular resistance and stroke volume will be calculated.;Autonomic modulation - evaluated by the measurement of heart rate and blood pressure variabilities (spectral analysis) performed before and after rest and resistance exercise while receiving placebo and captopril;Vascular function - evaluated by the measurement of baseline blood flow and its response to the reactive hyperemia maneuver (venous occlusion pletismography) performed before and after rest and resistance exercise while receiving placebo and captopril. | — |
Countries
Brazil
Contacts
Public ContactClaudia Forjaz
Escola de Educação Física e Esporte da Universidade de São Paulo
Outcome results
None listed