Pneumonia Ventilator-Associated
Conditions
Interventions
This is a double-blind, double-blind, randomized control trial. Control group: 10 patients of both sexes, admitted to an intensive care unit, on invasive mechanical ventilation, received oral hygiene
Sponsors
Universidade do Oeste de Santa Catarina
Hospital Unimed de Chapecó
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patients admitted to the Intensive Care Unit; on mechanical ventilation; older than 18 years
Exclusion criteria
Exclusion criteria: patients who had a current diagnosis and/or salivary gland disorders (Sjogren's syndrome, salivary gland tumor, parotitis); cancer patients regardless of the stage of the disease, psychiatric patients,; postoperative discharge within the first 24 hours; patients admitted from other institutions already on mechanical ventilation and oral and maxillofacial trauma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Patients who remain longer on mechanical ventilation are expected to suffer dysbiosis of the oral microbiome, increasing the risk of nosocomial infections. The diagnosis of the alteration of the oral microbiome will be carried out through the method of genetic sequencing of the oral biofilm. The analysis of the microbial community will be through the software QIIme (Quantitative Insights Into Microbial Ecology). The metagenomic sequences will be compared with already known sequences that are registered in national and international databases (reference sequences) to identify resistance genes and/or mutations. This allows us to compare OTUs (Operational Taxonomic Units) from different experiments.;Endpoint found 1: The analyzes of oral saliva samples from patients hospitalized in the intensive care unit of our study did not show a statistically significant difference in microbial communities between the groups, however the follow-up group showed a reduction in a richness index after the third day, which demonstrates that there was a negative effect on the microbial community in the patients receiving follow-up. | — |
Countries
Brazil
Contacts
Public ContactPaula Sachet
Universidade do Oeste de Santa Catarina
Outcome results
None listed