Infertility, female infertility.
Conditions
Interventions
GROUP 1: 30 patients
deep sedation by Fentanyl(1 mcg / kg) intravenously, followed by the administration of Propofol at a dose of bolus – 50 milligrams (50mg) intravenously, in titrated dose, registering the repeated valu
minimal sedation by Midazolam(0.075 mg/kg), associated to Remifentanil in continually at an initial dose of 0.25 micograms/kilo/minute (0.25 mcg/kg/min) and infiltration with 2 milliliters (ml) of lid
Drug
Procedure/surgery
Sponsors
Faculdade de Medicina do ABC
Centro de Reprodução Humana e Genética da Faculdade de Medicina do ABC
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women with the presence of at least one follicle bigger than 14 millimeters, to be punctured; Aged between 20 to 40 years old; with a diagnosis of infertility patients who attempted to spontaneous pregnancy for at least 12 months with regular sexual activity and without the use of contraceptives, however, failed to achieve pregnancy; Body Mass Index (BMI) between 20 and 30; Surgical risk by American Society of Anesthesiologists (ASA) 1 or 2.
Exclusion criteria
Exclusion criteria: Incomplete medical records; Carriers of chromosomal diseases; donor oocytes; Pathologies associeted with surgical risk ASA III, IV, V and VI; Presence of known allergy to anesthethic drugs used in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Finding difference between the number of punctured follicles in both groups, when subjected to different anesthetic techniques (sedation with propofol and fentanyl compared to sedation with midazolam and remifentanil, paracervical block) defines the value of standard deviation of 5.4 punctured follicles; difference of 4.3 punctured follicles to be detected; significance level of 5%, a power of 80% and a loss of approximately 10% (ARMITAGE & BERRY, 1987; Hammadhen et al, 1999). | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the vital signs parameters: heart rate, oxygen saturation, arterial pressure non-invasive. Compare importante questions in ambulatory anestesia: evaluate the Aldrete-Kroulik criteria in two and five minutes, and the required time to reach values of 10, this is a score that evaluates the degree of awakening of the patient so she can be released from the anesthetic recovery. | — |
Countries
Brazil
Contacts
Public ContactGilvandro de Oliveira Júnior
Faculdade de Medicina do ABC
Outcome results
None listed