Women
Conditions
Interventions
E05.318.308.980
In this observational study, a self-controlled clinical trial was conducted involving 20 women with BMI between 40 and 60 kg / m2, who were followed for a period of one year and six months. The object
Other
Sponsors
Instituto de Biociências de Botucatu - UNESP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Being female; Age between 20 and 45 years in menacme; Body Mass Index greater than 40 kg / m2 and less than 60 kg / m2; Waiting in the queue to perform the surgical procedure; Do not present diseases that cause changes in energy metabolism such as diabetes mellitus, hypothyroidism, HIV infection, neoplasms, heart diseases, nephropathies and liver diseases; Do not present diseases that cause edema such as venous insufficiency, pregnancy, thrombosis, sepsis, inflammation, lymphedema; Do not use medicines that cause metabolic and absorptive changes such as diuretics, amphetamines, thyroid hormones, topiramate, orlistat, corticosteroids, etc.
Exclusion criteria
Exclusion criteria: We excluded women who did not present optimal health conditions for the surgical procedure (diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies) after conducting the admission tests for the research and patients living outside the DRS-10 region (near the collection site).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: it is expected to verify if there is influence of bariatric surgery in the alterations of the total energy expenditure measured by the doubly-labeled water technique. This verification was evaluated based on the significant difference (p <0.05) in the energy expenditure measured at 6 and 12 months of surgery in relation to the preoperative period.;Outcome Found 1: It was verified that after the surgical procedure the total energy expenditure of the patients presented a reduction of 20% (p <0.05) at 6 months of surgery and 10% (p <0.05) at 12 months of surgery, when compared to values of total energy expenditure measured at the preoperative time. This result indicates the presence of energetic hypometabolism after the surgical procedure to treat obesity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2: With the application of the double-labeled water method, it was also expected to verify the relationship of changes in total energy expenditure with other factors related to changes in body weight in lean mass and fat mass verified by the methodology of stable isotope dilution and bioimpedance, changes in appetite and satiety hormones verified through genetic evaluation and changes in the level of physical activity analyzed by the accelerometer technique. Comparisons between the periods of data collection (pre-surgery, 6 and 12 months postoperatively) allowed to identify possible variables related to greater or lesser weight loss and the correlation between changes in food consumption, body composition and other variables components of energy expenditure with changes in the variable of total energy expenditure, when values between the periods showed a significant difference at the 5% level.;Outcome found 2: The changes in total energy expenditure were not related to body weight changes in total mass, lean mass and fat mass (P> 0.05) at six months of surgery, but at 12 months after surgery, Changes in body composition accounted for approximately 30% changes in energy expenditure. The changes in energy expenditure in physical activity, analyzed by the use of accelerometer, were associated (50% or more) with changes in total energy expenditure at 6 and 12 months of surgery (p <0.05). It was also verified that the predictive energy expenditure equations applied to the patients in the moments before and after 6 and 12 months of surgery present values above that measured by the doubly-labeled water technique, indicating the presence of overestimation of the energy requirement both when these patients are obese when after the presentation of significant weight loss. | — |
Countries
Brazil
Contacts
Public ContactMichele Ravelli
Instituto de Biociências de Botucatu - UNESP
Outcome results
None listed