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The effects of photobiomodulation on the gut-brain axis in adolescents with depression.

The effects of photobiomodulation on the gut-brain axis in adolescents with depression: a double-blind randomized controlled clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-8k52dw8
Enrollment
Unknown
Registered
2023-12-11
Start date
2024-01-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

It is a triple-blind study. The study will be carried out with 72 participants in the sample, 24 in the Intervention Group, 24 in the Experimental Group 1 and 24 in the Experimental Group 2. This stud
E02.594.540

Sponsors

Universidade do Sul de Santa Catarina
Lead Sponsor
Universidade do Sul de Santa Catarina
Collaborator

Eligibility

Age
15 Years to 17 Years

Inclusion criteria

Inclusion criteria: All individuals of both sexes aged 15 to 17 years with a diagnosis of depression made by a physician will be included in this study. Participants must be duly enrolled and attending schools of the 8th Regional Education Management (GERED) in Campos Novos/SC.

Exclusion criteria

Exclusion criteria: Participants with cognitive problems and unable to answer the questionnaires will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Assessing depressive symptoms in adolescents, as verified by the Hamilton Depression Rating Scale (HAM-D) method, which presents a score between 12-21 points, characterizing individuals evaluated with depression.

Secondary

MeasureTime frame
Assessing anxiety symptoms, Verified by the Hamilton Anxiety Scale (HAM-A) method, is an objective method of analyzing anxiety that is easy to apply and widely available. This scale has 14 items with groups describing behaviors related to the items, where each group is evaluated in degrees ranging from 0 (not at all) to 4 (maximum), with a total score of 56. High scores indicate high levels of anxiety.;Assessing the perception of stressful experiences in the previous month, verified by the Perceived Stress Scale (PSS) method. The tool consists of 14 items, seven positive and seven negative, with response options ranging from 0 to 4 (0 = never; 1 = almost never; 2 = sometimes; 3 = fairly often; 4 = very often). The items assess the occurrence of both negative and positive feelings, the ability to cope with stressful situations, as well as core components of stress in individuals.;To evaluate sleep quality, verified by the Pittsburgh Sleep Quality Index method, in the translated and validated version for Portuguese.;Assessing quality of life, verified by the Quality of Life method using the Portuguese version of the 12-Item Short-Form Health Survey (SF-12).;Assessing oxidative stress and levels of antioxidant enzymes, as well as analyzing mitochondrial function using 10 ml of blood collected from each participant.

Countries

Brazil

Contacts

Public ContactDaniel Martins

Universidade do Sul de Santa Catarina

danielmartinsfisio@hotmail.com+55(048)999185021

Outcome results

None listed

Source: REBEC (via WHO ICTRP)