Arthroplasty, Replacement, Knee
Conditions
Interventions
Each group will have 75 patients (150 in total). Patients undergoing total knee arthroplasty will be included and randomly assigned to two groups. The study group will receive a mechanical interventio
D09.698.373.400.300.200
Sponsors
Hospital Maradei
Faculdade de Medicina da Universidade de São Paulo (FMUSP)
Universidade Federal do Pará
Eligibility
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Adult patients submitted to total knee arthroplasty
Exclusion criteria
Exclusion criteria: Personal history of venous thromboembolism (deep vein thrombosis or pulmonary embolism); coagulation disorders; peptic ulcer disease; liver disease; enoxaparin allergy; malignant tumors; patients undergoing any surgery in the last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Evaluate the edema, measured in centimeters, by the circumference of the thigh, leg and ankle, 3 days after surgery. We expect the edema (thigh, leg and ankle) is greater with pharmacological thromboprophylaxis than with the mechanical method;Found outcome 1: Edema was greater in patients with pharmacological prophylaxis than with mechanical, at the three measured sites: thigh, leg and ankle, but this variation was statistically significant only in the leg (p equal to 0.002) and ankle (p lower than 0.001) | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2: Evaluate blood loss verified by the drain volume (ml) and the drop of hemoglobin (g/dl) and hematocrit rate(%), measured preoperatively and 48 h after surgery. We expect that blood loss is greater with pharmacological thromboprophylaxis than with the mechanical method. ;Found Outcome 2: the blood loss was greater in the pharmacological group, as seen by the drain volume (p lower than 0.001), as well as the drop in hemoglobin (p equal to 0.001) and hematocrit (p equal to 0.001). | — |
Countries
Brazil
Contacts
Public ContactJoão Alberto Maradei Pereira
Universidade Federal do Pará
Outcome results
None listed