Cardiovascular diseases
Conditions
Interventions
Will be studied 60 sedentary men with a historic of systemic arterial hypertension, aged between 35 and 65 years, will be allocated into three groups: hypertensive without pharmacological treatment, H
lipidogram, hemodynamic values
cardiorespiratory capacity
cardiovascular autonomic control through baroreflex sensitivity and heart rate and blood pressure variability analysis
and cardiac morphology and functionality through two-dimensional echocardiography.
E02.760.169.063.500.387
Sponsors
Faculdade de Medicina de Ribeirão Preto
Faculdade de Medicina de Ribeirão Preto
Eligibility
Sex/Gender
Male
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: Hypertensive men; sedentary; age 35 to 65 years; use of Enalapril Maleate or Losartan monotherapy; at least 6 months of pharmacological treatment; volunteers who, on medical recommendation, do not use antihypertensive drugs and who have the indication to perform aerobic physical training as the first therapeutic conduct in the treatment of hypertension
Exclusion criteria
Exclusion criteria: Cognitive impairment; musculoskeletal disorders; endocrine diseases; metabolic and cardiovascular diseases (except systemic arterial hypertension); smokers; use of combined drugs for hypertension or any other drug that interferes with cardiac functionality and cardiovascular autonomic control
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypertensive men who use the antihypertensive agents Enalapril Maleate or Losartan, as well as those who do not use medication to control blood pressure may present a decrease in sympathetic influence and increase in parasympathetic activity when evaluated by means of frequency spectral analysis and pre and post conditions the aerobic physical training program.;Hypertensive men may present metabolic alterations, evaluated through blood samples such as: increased glycemia and fasting insulin; increase in total cholesterol and fractions; increased triglycerides; increased C-reactive protein; increased levels of tumor necrosis factor alpha, interleukin-6, catecholamines and angiotensins I and II, these variables being influenced by the aerobic physical training program. | — |
Secondary
| Measure | Time frame |
|---|---|
| The aerobic physical training program may be able to promote in all hypertensive men, from the three groups, the improvement of cardiorespiratory and metabolic function, such as the anaerobic threshold and the volume of oxygen consumed at the peak of exercise (VO2peak), evaluated by means of of the ergospirometric test.;The aerobic physical training program may still be able to promote changes in body composition, lowering body weight and consequently decreasing body fat and, in some cases, may further promote lean body mass. | — |
Countries
Brazil
Contacts
Public ContactHugo;Tábata Souza;Facioli
Faculdade de Medicina de Ribeirão Preto - FMRP/USP;Faculdade de Medicina de Ribeirão Preto - FMRP/USP
Outcome results
None listed